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Exposure to Medical...
Exposure to Medical Radiation during Fetal Life, Childhood and Adolescence and Risk of Brain Tumor in Young Age: Results from The MOBI-Kids Case-Control Study
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Pasqual, E (author)
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Castano-Vinyals, G (author)
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Thierry-Chef, I (author)
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Kojimahara, N (author)
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Sim, MR (author)
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Kundi, M (author)
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Krewski, D (author)
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Momoli, F (author)
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Lacour, B (author)
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Remen, T (author)
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Radon, K (author)
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Weinmann, T (author)
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Petridou, E (author)
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Moschovi, M (author)
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Dikshit, R (author)
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Sadetski, S (author)
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Maule, M (author)
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Farinotti, M (author)
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Ha, M (author)
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Mannetje, A (author)
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Alguacil, J (author)
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Aragones, N (author)
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Vermeulen, R (author)
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Kromhout, H (author)
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Cardis, E (author)
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- 2020-03-20
- 2020
- English.
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In: Neuroepidemiology. - : S. Karger AG. - 1423-0208 .- 0251-5350. ; 54:4, s. 343-355
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http://repositori.up...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <b><i>Background:</i></b> We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. <b><i>Methods:</i></b> MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10–24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. <b><i>Results:</i></b> Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44–6.00) and 1.55 (0.57–4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. <b><i>Conclusions:</i></b> There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.
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- By the author/editor
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Pasqual, E
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Castano-Vinyals, ...
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Thierry-Chef, I
-
Kojimahara, N
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Sim, MR
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Kundi, M
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show more...
-
Krewski, D
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Momoli, F
-
Lacour, B
-
Remen, T
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Radon, K
-
Weinmann, T
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Petridou, E
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Moschovi, M
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Dikshit, R
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Sadetski, S
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Maule, M
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Farinotti, M
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Ha, M
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Mannetje, A
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Alguacil, J
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Aragones, N
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Vermeulen, R
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Kromhout, H
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Cardis, E
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show less...
- Articles in the publication
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Neuroepidemiolog ...
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Karolinska Institutet