Skin T cells maintain their diversity and functionality in the elderly

Cheuk, S (author)

Matsumura, Y (author)

Vo, S (author)

Kjellman, P (author)

Grema, L (author)

Ishitsuka, Y (author)

Nakamura, Y (author)

Okiyama, N (author)

Fujisawa, Y (author)

Fujimoto, M (author)

Clark, RA (author)

Watanabe, R (author)

(creator_code:org_t)

2021-01-04
2021
English.
In: Communications biology. - : Springer Science and Business Media LLC. - 2399-3642. ; 4:1, s. 13-

Related links:: https://www.nature.c...; show more...; http://kipublication...; https://doi.org/10.1...; show less...

Abstract Subject headings

Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.

By the author/editor: Koguchi-Yoshioka ...; Hoffer, E; Cheuk, S; Matsumura, Y; Vo, S; Kjellman, P; show more...; Grema, L; Ishitsuka, Y; Nakamura, Y; Okiyama, N; Fujisawa, Y; Fujimoto, M; Eidsmo, L; Clark, RA; Watanabe, R; show less...

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