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  • Koguchi-Yoshioka, HKarolinska Institutet (author)

Skin T cells maintain their diversity and functionality in the elderly

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-04
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:145672187
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145672187URI
  • https://doi.org/10.1038/s42003-020-01551-7DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hoffer, EKarolinska Institutet (author)
  • Cheuk, S (author)
  • Matsumura, Y (author)
  • Vo, S (author)
  • Kjellman, P (author)
  • Grema, L (author)
  • Ishitsuka, Y (author)
  • Nakamura, Y (author)
  • Okiyama, N (author)
  • Fujisawa, Y (author)
  • Fujimoto, M (author)
  • Eidsmo, LKarolinska Institutet (author)
  • Clark, RA (author)
  • Watanabe, R (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Communications biology: Springer Science and Business Media LLC4:1, s. 13-2399-3642

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