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Skin T cells mainta...
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Koguchi-Yoshioka, HKarolinska Institutet
(author)
Skin T cells maintain their diversity and functionality in the elderly
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-04
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:145672187
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145672187URI
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https://doi.org/10.1038/s42003-020-01551-7DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Recent studies have highlighted that human resident memory T cells (TRM) are functionally distinct from circulating T cells. Thus, it can be postulated that skin T cells age differently from blood-circulating T cells. We assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries. No decline in the density of T cells was noted with advancing age, and the frequency of epidermal CD49a+ CD8 TRM was increased in elderly individuals regardless of ethnicity. T-cell diversity and antipathogen responses were maintained in the skin of elderly individuals but declined in the blood. Our findings demonstrate that in elderly individuals, skin T cells maintain their density, diversity, and protective cytokine production despite the reduced T-cell diversity and function in blood. Skin resident T cells may represent a long-lived, highly protective reservoir of immunity in elderly people.
Added entries (persons, corporate bodies, meetings, titles ...)
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Hoffer, EKarolinska Institutet
(author)
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Cheuk, S
(author)
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Matsumura, Y
(author)
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Vo, S
(author)
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Kjellman, P
(author)
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Grema, L
(author)
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Ishitsuka, Y
(author)
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Nakamura, Y
(author)
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Okiyama, N
(author)
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Fujisawa, Y
(author)
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Fujimoto, M
(author)
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Eidsmo, LKarolinska Institutet
(author)
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Clark, RA
(author)
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Watanabe, R
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Communications biology: Springer Science and Business Media LLC4:1, s. 13-2399-3642
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Koguchi-Yoshioka ...
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Hoffer, E
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Cheuk, S
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Matsumura, Y
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Vo, S
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Kjellman, P
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Grema, L
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Ishitsuka, Y
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Nakamura, Y
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Okiyama, N
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Fujisawa, Y
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Fujimoto, M
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Eidsmo, L
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Clark, RA
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Watanabe, R
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Communications b ...
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Karolinska Institutet