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1H, 13C and 15N che...
1H, 13C and 15N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-23
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:145712860
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145712860URI
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https://doi.org/10.1007/s12104-021-10007-wDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5′- and 3′-genomic ends of the 30 kb SCoV-2 genome are potential antiviral drug targets. Major parts of these sequences are highly conserved among Betacoronaviruses and contain cis-acting RNA elements that affect RNA translation and replication. The 31 nucleotide (nt) long highly conserved stem-loop 5a (SL5a) is located within the 5′-untranslated region (5′-UTR) important for viral replication. SL5a features a U-rich asymmetric bulge and is capped with a 5′-UUUCGU-3′ hexaloop, which is also found in stem-loop 5b (SL5b). We herein report the extensive 1H, 13C and 15N resonance assignment of SL5a as basis for in-depth structural studies by solution NMR spectroscopy.
Added entries (persons, corporate bodies, meetings, titles ...)
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Peter, SA
(author)
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Banijamali, E
(author)
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Riad, M
(author)
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Altincekic, N
(author)
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Bains, JK
(author)
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Ceylan, B
(author)
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Furtig, B
(author)
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Grun, JT
(author)
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Hengesbach, M
(author)
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Hohmann, KF
(author)
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Hymon, D
(author)
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Knezic, B
(author)
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Oxenfarth, A
(author)
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Petzold, KKarolinska Institutet
(author)
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Qureshi, NS
(author)
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Richter, C
(author)
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Schlagnitweit, J
(author)
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Schlundt, A
(author)
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Schwalbe, H
(author)
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Stirnal, E
(author)
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Sudakov, A
(author)
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Vogele, J
(author)
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Wacker, A
(author)
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Weigand, JE
(author)
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Wirmer-Bartoschek, J
(author)
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Wohnert, J
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Biomolecular NMR assignments: Springer Science and Business Media LLC15:1, s. 203-2111874-270X1874-2718
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Schnieders, R
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Peter, SA
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Banijamali, E
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Riad, M
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Altincekic, N
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Bains, JK
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Ceylan, B
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Furtig, B
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Grun, JT
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Hengesbach, M
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Hohmann, KF
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Hymon, D
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Knezic, B
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Oxenfarth, A
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Petzold, K
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Qureshi, NS
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Richter, C
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Schlagnitweit, J
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Schlundt, A
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Schwalbe, H
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Stirnal, E
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Sudakov, A
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Vogele, J
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Wacker, A
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Weigand, JE
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Wirmer-Bartosche ...
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Wohnert, J
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Biomolecular NMR ...
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Karolinska Institutet