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Stimulating the Res...
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Arnardottir, HKarolinska Institutet
(author)
Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-01-11
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Frontiers Media SA,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:145719494
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145719494URI
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https://doi.org/10.3389/fphys.2020.624657DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction. Excessive inflammation has been reported in severe cases with respiratory failure and cardiovascular complications. In addition to the release of cytokines, referred to as cytokine release syndrome or “cytokine storm,” increased pro-inflammatory lipid mediators derived from the omega-6 polyunsaturated fatty acid (PUFA) arachidonic acid may cause an “eicosanoid storm,” which contributes to the uncontrolled systemic inflammation. Specialized pro-resolving mediators, which are derived from omega-3 PUFA, limit inflammatory reactions by an active process called resolution of inflammation. Here, the rationale for omega-3 PUFA supplementation in COVID-19 patients is presented along with a brief overview of the study protocol for the trial “Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A single-blind, randomized, placebo-controlled feasibility study” (COVID-Omega-F). EudraCT: 2020-002293-28; clinicaltrials.gov: NCT04647604.
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Pawelzik, SCKarolinska Institutet
(author)
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Wistbacka, UO
(author)
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Artiach, G
(author)
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Hofmann, RKarolinska Institutet
(author)
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Reinholdsson, I
(author)
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Braunschweig, FKarolinska Institutet
(author)
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Tornvall, PKarolinska Institutet
(author)
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Religa, DKarolinska Institutet
(author)
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Back, MKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Frontiers in physiology: Frontiers Media SA11, s. 624657-1664-042X
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Arnardottir, H
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Pawelzik, SC
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Wistbacka, UO
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Artiach, G
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Hofmann, R
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Reinholdsson, I
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Braunschweig, F
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Tornvall, P
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Religa, D
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Back, M
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Frontiers in phy ...
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Karolinska Institutet