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Automated digital T...
Automated digital TIL analysis (ADTA) adds prognostic value to standard assessment of depth and ulceration in primary melanoma
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Moore, MR (author)
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Friesner, ID (author)
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Rizk, EM (author)
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Fullerton, BT (author)
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Mondal, M (author)
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Trager, MH (author)
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Mendelson, K (author)
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Chikeka, I (author)
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Kurc, T (author)
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Gupta, R (author)
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Rohr, BR (author)
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Robinson, EJ (author)
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- Acs, B (author)
- Karolinska Institutet
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Chang, R (author)
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Kluger, H (author)
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Taback, B (author)
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Geskin, LJ (author)
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Horst, B (author)
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Gardner, K (author)
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Niedt, G (author)
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Celebi, JT (author)
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Gartrell-Corrado, RD (author)
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Messina, J (author)
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Ferringer, T (author)
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Rimm, DL (author)
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Saltz, J (author)
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Wang, J (author)
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Vanguri, R (author)
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Saenger, YM (author)
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(creator_code:org_t)
- 2021-02-02
- 2021
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 2809-
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Abstract
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- Accurate prognostic biomarkers in early-stage melanoma are urgently needed to stratify patients for clinical trials of adjuvant therapy. We applied a previously developed open source deep learning algorithm to detect tumor-infiltrating lymphocytes (TILs) in hematoxylin and eosin (H&E) images of early-stage melanomas. We tested whether automated digital (TIL) analysis (ADTA) improved accuracy of prediction of disease specific survival (DSS) based on current pathology standards. ADTA was applied to a training cohort (n = 80) and a cutoff value was defined based on a Receiver Operating Curve. ADTA was then applied to a validation cohort (n = 145) and the previously determined cutoff value was used to stratify high and low risk patients, as demonstrated by Kaplan–Meier analysis (p ≤ 0.001). Multivariable Cox proportional hazards analysis was performed using ADTA, depth, and ulceration as co-variables and showed that ADTA contributed to DSS prediction (HR: 4.18, CI 1.51–11.58, p = 0.006). ADTA provides an effective and attainable assessment of TILs and should be further evaluated in larger studies for inclusion in staging algorithms.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Moore, MR
-
Friesner, ID
-
Rizk, EM
-
Fullerton, BT
-
Mondal, M
-
Trager, MH
-
show more...
-
Mendelson, K
-
Chikeka, I
-
Kurc, T
-
Gupta, R
-
Rohr, BR
-
Robinson, EJ
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Acs, B
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Chang, R
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Kluger, H
-
Taback, B
-
Geskin, LJ
-
Horst, B
-
Gardner, K
-
Niedt, G
-
Celebi, JT
-
Gartrell-Corrado ...
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Messina, J
-
Ferringer, T
-
Rimm, DL
-
Saltz, J
-
Wang, J
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Vanguri, R
-
Saenger, YM
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show less...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet