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The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study
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Colombo, GI (author)
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Bianconi, V (author)
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Bonomi, A (author)
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Simonelli, S (author)
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Amato, M (author)
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Frigerio, B (author)
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Ravani, A (author)
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Vitali, C (author)
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Sansaro, D (author)
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Coggi, D (author)
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Mannarino, MR (author)
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Savonen, KP (author)
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Kurl, S (author)
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- Gigante, B (author)
- Karolinska Institutet
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Smit, AJ (author)
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Giral, P (author)
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Tremoli, E (author)
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Calabresi, L (author)
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Veglia, F (author)
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Pirro, M (author)
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Baldassarre, D (author)
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(creator_code:org_t)
- 2021-03-11
- 2021
- English.
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In: Biomedicines. - : MDPI AG. - 2227-9059. ; 9:3
- Related links:
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https://www.mdpi.com...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- The impact of cholesteryl ester transfer protein (CETP) on atherosclerosis is highly debated. This study aimed to investigate the associations between plasma CETP or CETP genotypes and carotid intima-media thickness (cIMT) and the influence of high-density lipoprotein cholesterol (HDL-C) on these associations. Plasma CETP and HDL-C concentrations were measured in 552 subjects free of any pharmacological treatment from the IMPROVE cohort, which includes 3711 European subjects at high cardiovascular risk. CETP single-nucleotide polymorphisms (SNPs) and cIMT measures (cIMTmax; cIMTmean–max of bifurcations, common and internal carotids; plaque-free common carotid [PF CC]-IMTmean) were available for the full cohort. In drug-free subjects, plasma CETP correlated with HDL-C levels (r = 0.19, p < 0.0001), but not with cIMT variables. When stratified according to HDL-C quartiles, CETP positively correlated with cIMTmax and cIMTmean–max, but not with PF CC-IMTmean, in the top HDL-C quartile only. Positive associations between the CETP concentration and cIMTmax or cIMTmean–max were found in the top HDL-C quartile, whereas HDL-C levels were negatively correlated with cIMTmax and cIMTmean–max when the CETP concentration was below the median (HDL-C × CETP interaction, p = 0.001 and p = 0.003 for cIMTmax and cIMTmean–max, respectively). In the full cohort, three CETP SNPs (rs34760410, rs12920974, rs12708968) were positively associated with cIMTmax. rs12444708 exhibited a significant interaction with HDL-C levels in the prediction of cIMTmax. In conclusion, a significant interplay was found between plasma CETP and/or CETP genotype and HDL-C in the prediction of carotid plaque thickness, as indexed by cIMTmax. This suggests that the association of HDL-C with carotid atherosclerosis is CETP-dependent.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Colombo, GI
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Bianconi, V
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Bonomi, A
-
Simonelli, S
-
Amato, M
-
Frigerio, B
-
show more...
-
Ravani, A
-
Vitali, C
-
Sansaro, D
-
Coggi, D
-
Mannarino, MR
-
Savonen, KP
-
Kurl, S
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Gigante, B
-
Smit, AJ
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Giral, P
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Tremoli, E
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Calabresi, L
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Veglia, F
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Pirro, M
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Baldassarre, D
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show less...
- Articles in the publication
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Biomedicines
- By the university
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Karolinska Institutet