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Genome-wide associa...
Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study
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Meng, L (author)
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Qin, XY (author)
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Peng, HX (author)
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Gao, WJ (author)
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Sara, H (author)
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Cao, WH (author)
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Li, CX (author)
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Yu, CQ (author)
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Lv, J (author)
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Pang, ZC (author)
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Cong, LM (author)
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Wang, H (author)
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Wu, XP (author)
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Wang, YZ (author)
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Li, LM (author)
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- Future Medicine Ltd, 2021
- 2021
- English.
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In: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 13:12, s. 939-951
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https://doi.org/10.2...
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Abstract
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- Aim: Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. Materials & methods: In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Results: Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. Conclusion: The hypermethylation of cg07326074, located in the tumor-promoting gene C16orf59, was associated with alcohol consumption.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Meng, L
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Qin, XY
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Peng, HX
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Gao, WJ
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Sara, H
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Cao, WH
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show more...
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Li, CX
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Yu, CQ
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Lv, J
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Pang, ZC
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Cong, LM
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Wang, H
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Wu, XP
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Wang, YZ
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Li, LM
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show less...
- Articles in the publication
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Epigenomics
- By the university
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Karolinska Institutet