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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02733naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146693920 | |
| 003 | SwePub | |
| 008 | 240902s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1466939202 URI |
| 024 | 7 | a https://doi.org/10.26508/lsa.2020007232 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Luu, TT4 aut |
| 245 | 1 0 | a Short-term IL-15 priming leaves a long-lasting signalling imprint in mouse NK cells independently of a metabolic switch |
| 264 | c 2021-02-16 | |
| 264 | 1 | b Life Science Alliance, LLC,c 2021 |
| 520 | a IL-15 priming of NK cells is a broadly accepted concept, but the dynamics and underlying molecular mechanisms remain poorly understood. We show that as little as 5 min of IL-15 treatment in vitro, followed by removal of excess cytokines, results in a long-lasting, but reversible, augmentation of NK cell responsiveness upon activating receptor cross-linking. In contrast to long-term stimulation, improved NK cell function after short-term IL-15 priming was not associated with enhanced metabolism but was based on the increased steady-state phosphorylation level of signalling molecules downstream of activating receptors. Inhibition of JAK3 eliminated this priming effect, suggesting a cross talk between the IL-15 receptor and ITAM-dependent activating receptors. Increased signalling molecule phosphorylation levels, calcium flux, and IFN-γ secretion lasted for up to 3 h after IL-15 stimulation before returning to baseline. We conclude that IL-15 rapidly and reversibly primes NK cell function by modulating activating receptor signalling. Our findings suggest a mechanism by which NK cell reactivity can potentially be maintained in vivo based on only brief encounters with IL-15 trans-presenting cells. | |
| 700 | 1 | a Schmied, L4 aut |
| 700 | 1 | a Nguyen, NA4 aut |
| 700 | 1 | a Wiel, C4 aut |
| 700 | 1 | a Meinke, Su Karolinska Institutet4 aut |
| 700 | 1 | a Mohammad, DKu Karolinska Institutet4 aut |
| 700 | 1 | a Bergo, Mu Karolinska Institutet4 aut |
| 700 | 1 | a Alici, Eu Karolinska Institutet4 aut |
| 700 | 1 | a Kadri, Nu Karolinska Institutet4 aut |
| 700 | 1 | a Ganesan, S4 aut |
| 700 | 1 | a Hoglund, Pu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Life science allianced : Life Science Alliance, LLCg 4:4q 4:4x 2575-1077 |
| 856 | 4 | u https://www.life-science-alliance.org/content/lsa/4/4/e202000723.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146693920 |
| 856 | 4 8 | u https://doi.org/10.26508/lsa.202000723 |
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