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Genome-wide bioinfo...
Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-05-17
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146743439
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146743439URI
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https://doi.org/10.1038/s42003-021-02095-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we analyzed public host and viral RNA sequencing data to better understand how SARS-CoV-2 interacts with human respiratory cells. We identified genes, isoforms and transposable element families that are specifically altered in SARS-CoV-2-infected respiratory cells. Well-known immunoregulatory genes including CSF2, IL32, IL-6 and SERPINA3 were differentially expressed, while immunoregulatory transposable element families were upregulated. We predicted conserved interactions between the SARS-CoV-2 genome and human RNA-binding proteins such as the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and eukaryotic initiation factor 4 (eIF4b). We also identified a viral sequence variant with a statistically significant skew associated with age of infection, that may contribute to intracellular host–pathogen interactions. These findings can help identify host mechanisms that can be targeted by prophylactics and/or therapeutics to reduce the severity of COVID-19.
Added entries (persons, corporate bodies, meetings, titles ...)
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Lal, A
(author)
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Rebollo, R
(author)
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Gruber, AJ
(author)
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Guarracino, A
(author)
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Gonzalez, IMKarolinska Institutet
(author)
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Floyd, T
(author)
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de Oliveira, DS
(author)
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Shanklin, J
(author)
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Beausoleil, E
(author)
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Pusa, T
(author)
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Pickett, BE
(author)
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Aguiar-Pulido, V
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Communications biology: Springer Science and Business Media LLC4:1, s. 590-2399-3642
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Ferrarini, MG
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Lal, A
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Rebollo, R
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Gruber, AJ
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Guarracino, A
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Gonzalez, IM
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show more...
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Floyd, T
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de Oliveira, DS
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Shanklin, J
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Beausoleil, E
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Pusa, T
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Pickett, BE
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Aguiar-Pulido, V
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- Articles in the publication
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Communications b ...
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Karolinska Institutet