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COVID-19 pathophysi...
COVID-19 pathophysiology may be driven by an imbalance in the renin-angiotensin-aldosterone system
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- Rysz, S (author)
- Karolinska Institutet
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- Al-Saadi, J (author)
- Karolinska Institutet
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- Sjostrom, A (author)
- Karolinska Institutet
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- Farm, M (author)
- Karolinska Institutet
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- Jalde, FC (author)
- Karolinska Institutet
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- Platten, M (author)
- Karolinska Institutet
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- Eriksson, Helen (author)
- Stockholms universitet,Sociologiska institutionen
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Klein, M (author)
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Vargas-Paris, R (author)
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- Nyren, S (author)
- Karolinska Institutet
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Abdula, G (author)
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- Ouellette, R (author)
- Karolinska Institutet
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- Granberg, T (author)
- Karolinska Institutet
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- Fagerlund, MJ (author)
- Karolinska Institutet
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- Lundberg, J (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-04-23
- 2021
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 2417-
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https://doi.org/10.1...
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Abstract
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- SARS-CoV-2 uses ACE2, an inhibitor of the Renin-Angiotensin-Aldosterone System (RAAS), for cellular entry. Studies indicate that RAAS imbalance worsens the prognosis in COVID-19. We present a consecutive retrospective COVID-19 cohort with findings of frequent pulmonary thromboembolism (17%), high pulmonary artery pressure (60%) and lung MRI perfusion disturbances. We demonstrate, in swine, that infusing angiotensin II or blocking ACE2 induces increased pulmonary artery pressure, reduces blood oxygenation, increases coagulation, disturbs lung perfusion, induces diffuse alveolar damage, and acute tubular necrosis compared to control animals. We further demonstrate that this imbalanced state can be ameliorated by infusion of an angiotensin receptor blocker and low-molecular-weight heparin. In this work, we show that a pathophysiological state in swine induced by RAAS imbalance shares several features with the clinical COVID-19 presentation. Therefore, we propose that severe COVID-19 could partially be driven by a RAAS imbalance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rysz, S
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Al-Saadi, J
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Sjostrom, A
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Farm, M
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Jalde, FC
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Platten, M
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show more...
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Eriksson, Helen
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Klein, M
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Vargas-Paris, R
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Nyren, S
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Abdula, G
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Ouellette, R
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Granberg, T
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Fagerlund, MJ
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Lundberg, J
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet
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Stockholm University