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Severe liver diseas...
Severe liver disease resembling PSC in mice with K5-Cre mediated deletion of Krüppel-like factor 5 (Klf5)
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-06-11
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:146849649
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146849649URI
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https://doi.org/10.1007/s11248-021-00267-6DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chronic cholestatic liver diseases including primary sclerosing cholangitis (PSC) present a complex spectrum with regards to the cause, age of manifestation and histopathological features. Current treatment options are severely limited primarily due to a paucity of model systems mirroring the disease. Here, we describe the Keratin 5 (K5)-Cre; Klf5fl/fl mouse that spontaneously develops severe liver disease during the postnatal period with features resembling PSC including a prominent ductular reaction, fibrotic obliteration of the bile ducts and secondary degeneration/necrosis of liver parenchyma. Over time, there is an expansion of Sox9+ hepatocytes in the damaged livers suggestive of a hepatocyte-mediated regenerative response. We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver.
Added entries (persons, corporate bodies, meetings, titles ...)
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Gerling, MKarolinska Institutet
(author)
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Van Hul, NKarolinska Institutet
(author)
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Moro, CFKarolinska Institutet
(author)
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Rozell, B
(author)
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Toftgard, RKarolinska Institutet
(author)
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Sur, IKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Transgenic research: Springer Science and Business Media LLC30:5, s. 701-7071573-93680962-8819
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