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Clonal evolution an...
Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
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Ochi, Y (author)
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Yoshida, K (author)
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Huang, YJ (author)
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Kuo, MC (author)
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Nannya, Y (author)
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Sasaki, K (author)
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Mitani, K (author)
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Hosoya, N (author)
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Hiramoto, N (author)
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Ishikawa, T (author)
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Branford, S (author)
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Shanmuganathan, N (author)
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Ohyashiki, K (author)
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Takahashi, N (author)
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Takaku, T (author)
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Tsuchiya, S (author)
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Kanemura, N (author)
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Nakamura, N (author)
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Ueda, Y (author)
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Yoshihara, S (author)
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Bera, R (author)
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Shiozawa, Y (author)
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Zhao, LY (author)
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Takeda, J (author)
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Watatani, Y (author)
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Okuda, R (author)
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Makishima, H (author)
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Shiraishi, Y (author)
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Chiba, K (author)
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Tanaka, H (author)
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Sanada, M (author)
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Takaori-Kondo, A (author)
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Miyano, S (author)
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Ogawa, S (author)
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Shih, LEY (author)
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- 2021-05-14
- 2021
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1, s. 2833-
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Ochi, Y
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Yoshida, K
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Huang, YJ
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Kuo, MC
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Nannya, Y
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Sasaki, K
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show more...
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Mitani, K
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Hosoya, N
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Hiramoto, N
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Ishikawa, T
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Branford, S
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Shanmuganathan, ...
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Ohyashiki, K
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Takahashi, N
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Takaku, T
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Tsuchiya, S
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Kanemura, N
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Nakamura, N
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Ueda, Y
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Yoshihara, S
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Bera, R
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Shiozawa, Y
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Zhao, LY
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Takeda, J
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Watatani, Y
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Okuda, R
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Makishima, H
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Shiraishi, Y
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Chiba, K
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Tanaka, H
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Sanada, M
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Takaori-Kondo, A
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Miyano, S
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Ogawa, S
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Shih, LEY
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet