Search: onr:"swepub:oai:prod.swepub.kib.ki.se:147122722" >
Therapeutic Cancer ...
Therapeutic Cancer Vaccination with Immunopeptidomics-Discovered Antigens Confers Protective Antitumor Efficacy
-
Peltonen, K (author)
-
Feola, S (author)
-
- Umer, HM (author)
- Karolinska Institutet
-
show more...
-
Chiaro, J (author)
-
Mermelekas, G (author)
-
Ylosmaki, E (author)
-
Pesonen, S (author)
-
- Branca, RMM (author)
- Karolinska Institutet
-
- Lehtio, J (author)
- Karolinska Institutet
-
Cerullo, V (author)
-
show less...
-
(creator_code:org_t)
- 2021-07-07
- 2021
- English.
-
In: Cancers. - : MDPI AG. - 2072-6694. ; 13:14
- Related links:
-
https://www.mdpi.com...
-
show more...
-
http://kipublication...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Knowledge of clinically targetable tumor antigens is becoming vital for broader design and utility of therapeutic cancer vaccines. This information is obtained reliably by directly interrogating the MHC-I presented peptide ligands, the immunopeptidome, with state-of-the-art mass spectrometry. Our manuscript describes direct identification of novel tumor antigens for an aggressive triple-negative breast cancer model. Immunopeptidome profiling revealed 2481 unique antigens, among them a novel ERV antigen originating from an endogenous retrovirus element. The clinical benefit and tumor control potential of the identified tumor antigens and ERV antigen were studied in a preclinical model using two vaccine platforms and therapeutic settings. Prominent control of established tumors was achieved using an oncolytic adenovirus platform designed for flexible and specific tumor targeting, namely PeptiCRAd. Our study presents a pipeline integrating immunopeptidome analysis-driven antigen discovery with a therapeutic cancer vaccine platform for improved personalized oncolytic immunotherapy.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Peltonen, K
-
Feola, S
-
Umer, HM
-
Chiaro, J
-
Mermelekas, G
-
Ylosmaki, E
-
show more...
-
Pesonen, S
-
Branca, RMM
-
Lehtio, J
-
Cerullo, V
-
show less...
- Articles in the publication
-
Cancers
- By the university
-
Karolinska Institutet