SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:prod.swepub.kib.ki.se:147565973"
 

Search: onr:"swepub:oai:prod.swepub.kib.ki.se:147565973" > A comprehensive ris...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Zhou, X (author)

A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-08-31
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:147565973
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147565973URI
  • https://doi.org/10.1038/s41467-021-25402-zDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12–37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Cao, SM (author)
  • Cai, YL (author)
  • Zhang, X (author)
  • Zhang, SS (author)
  • Feng, GF (author)
  • Chen, YFKarolinska Institutet (author)
  • Feng, QS (author)
  • Chen, YJ (author)
  • Chang, ET (author)
  • Liu, ZH (author)
  • Adami, HOKarolinska Institutet (author)
  • Liu, JJ (author)
  • Ye, WMKarolinska Institutet (author)
  • Zhang, Z (author)
  • Zeng, YX (author)
  • Xu, M (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC12:1, s. 5189-2041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view