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A comprehensive ris...
A comprehensive risk score for effective risk stratification and screening of nasopharyngeal carcinoma
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-08-31
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147565973
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147565973URI
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https://doi.org/10.1038/s41467-021-25402-zDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Using Epstein-Barr virus (EBV)-based markers to screen populations at high risk for nasopharyngeal carcinoma (NPC) is an attractive preventive approach. Here, we develop a comprehensive risk score (CRS) that combines risk effects of EBV and human genetics for NPC risk stratification and validate this CRS within an independent, population-based dataset. Comparing the top decile with the bottom quintile of CRSs, the odds ratio of developing NPC is 21 (95% confidence interval: 12–37) in the validation dataset. When combining the top quintile of CRS with EBV serology tests currently used for NPC screening in southern China, the positive prediction value of screening increases from 4.70% (serology test alone) to 43.24% (CRS plus serology test). By identifying individuals at a monogenic level of NPC risk, this CRS approach provides opportunities for personalized risk prediction and population screening in endemic areas for the early diagnosis and secondary prevention of NPC.
Added entries (persons, corporate bodies, meetings, titles ...)
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Cao, SM
(author)
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Cai, YL
(author)
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Zhang, X
(author)
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Zhang, SS
(author)
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Feng, GF
(author)
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Chen, YFKarolinska Institutet
(author)
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Feng, QS
(author)
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Chen, YJ
(author)
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Chang, ET
(author)
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Liu, ZH
(author)
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Adami, HOKarolinska Institutet
(author)
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Liu, JJ
(author)
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Ye, WMKarolinska Institutet
(author)
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Zhang, Z
(author)
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Zeng, YX
(author)
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Xu, M
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC12:1, s. 5189-2041-1723
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Zhou, X
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Cao, SM
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Cai, YL
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Zhang, X
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Zhang, SS
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Feng, GF
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Chen, YF
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Feng, QS
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Chen, YJ
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Chang, ET
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Liu, ZH
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Adami, HO
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Liu, JJ
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Ye, WM
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Zhang, Z
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Zeng, YX
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Xu, M
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Nature communica ...
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Karolinska Institutet