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SARS-CoV-2 infectio...
SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
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Jing, YK (author)
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Luo, L (author)
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Chen, Y (author)
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- Westerberg, LS (author)
- Karolinska Institutet
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Zhou, P (author)
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Xu, ZP (author)
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Herrada, AA (author)
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Park, CS (author)
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Kubo, M (author)
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Mei, H (author)
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Hu, Y (author)
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Lee, PPW (author)
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Zheng, B (author)
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Sui, ZW (author)
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Xiao, W (author)
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Gong, Q (author)
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Lu, ZX (author)
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Liu, CH (author)
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(creator_code:org_t)
- 2021-09-22
- 2021
- English.
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In: Signal transduction and targeted therapy. - : Springer Science and Business Media LLC. - 2059-3635. ; 6:1, s. 345-
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
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- The SARS-CoV-2 infection causes severe immune disruption. However, it is unclear if disrupted immune regulation still exists and pertains in recovered COVID-19 patients. In our study, we have characterized the immune phenotype of B cells from 15 recovered COVID-19 patients, and found that healthy controls and recovered patients had similar B-cell populations before and after BCR stimulation, but the frequencies of PBC in patients were significantly increased when compared to healthy controls before stimulation. However, the percentage of unswitched memory B cells was decreased in recovered patients but not changed in healthy controls upon BCR stimulation. Interestingly, we found that CD19 expression was significantly reduced in almost all the B-cell subsets in recovered patients. Moreover, the BCR signaling and early B-cell response were disrupted upon BCR stimulation. Mechanistically, we found that the reduced CD19 expression was caused by the dysregulation of cell metabolism. In conclusion, we found that SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism, which may provide a new intervention target to cure COVID-19.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Jing, YK
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Luo, L
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Chen, Y
-
Westerberg, LS
-
Zhou, P
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Xu, ZP
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show more...
-
Herrada, AA
-
Park, CS
-
Kubo, M
-
Mei, H
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Hu, Y
-
Lee, PPW
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Zheng, B
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Sui, ZW
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Xiao, W
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Gong, Q
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Lu, ZX
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Liu, CH
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show less...
- Articles in the publication
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Signal transduct ...
- By the university
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Karolinska Institutet