Search: onr:"swepub:oai:prod.swepub.kib.ki.se:147695604" >
CD4+ T cells in the...
CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope
-
Greaves, SA (author)
-
Ravindran, A (author)
-
Santos, RG (author)
-
show more...
-
Chen, L (author)
-
Falta, MT (author)
-
Wang, Y (author)
-
Mitchell, AM (author)
-
Atif, SM (author)
-
Mack, DG (author)
-
Tinega, AN (author)
-
Maier, LA (author)
-
Dai, SD (author)
-
Pinilla, C (author)
-
- Grunewald, J (author)
- Karolinska Institutet
-
Fontenot, AP (author)
-
show less...
-
(creator_code:org_t)
- 2021-08-19
- 2021
- English.
-
In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:10
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Löfgren’s syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 (NDPD) of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner. Using ELISPOT analysis, a greater number of IFN-γ– and IL-2–secreting T cells in the BAL of DR3+ LS subjects compared with DR3+ control subjects was observed in response to the NDPD peptide. Finally, increased IgG antibody responses to A. nidulans NDPD were detected in the serum of DR3+ LS subjects. Thus, our findings identify a ligand for CD4+ T cells derived from the lungs of LS patients and suggest a role of A. nidulans in the etiology of LS.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Greaves, SA
-
Ravindran, A
-
Santos, RG
-
Chen, L
-
Falta, MT
-
Wang, Y
-
show more...
-
Mitchell, AM
-
Atif, SM
-
Mack, DG
-
Tinega, AN
-
Maier, LA
-
Dai, SD
-
Pinilla, C
-
Grunewald, J
-
Fontenot, AP
-
show less...
- Articles in the publication
-
The Journal of e ...
- By the university
-
Karolinska Institutet