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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 09582naa a2202689 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:147696770 | |
| 003 | SwePub | |
| 008 | 240818s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1476967702 URI |
| 024 | 7 | a https://doi.org/10.1136/bjophthalmol-2020-3166132 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fabian, ID4 aut |
| 245 | 1 0 | a Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries |
| 264 | c 2020-09-15 | |
| 264 | 1 | b BMJ,c 2021 |
| 520 | a The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed to investigate the travel burden and its impact on clinical presentation in a large sample of patients with retinoblastoma from Africa and Europe.MethodsA cross-sectional analysis including 518 treatment-naïve patients with retinoblastoma residing in 40 European countries and 1024 treatment-naïve patients with retinoblastoma residing in 43 African countries.ResultsCapture rate was 42.2% of expected patients from Africa and 108.8% from Europe. African patients were older (95% CI −12.4 to −5.4, p<0.001), had fewer cases of familial retinoblastoma (95% CI 2.0 to 5.3, p<0.001) and presented with more advanced disease (95% CI 6.0 to 9.8, p<0.001); 43.4% and 15.4% of Africans had extraocular retinoblastoma and distant metastasis at the time of diagnosis, respectively, compared to 2.9% and 1.0% of the Europeans. To reach a retinoblastoma centre, European patients travelled 421.8 km compared to Africans who travelled 185.7 km (p<0.001). On regression analysis, lower-national income level, African residence and older age (p<0.001), but not travel distance (p=0.19), were risk factors for advanced disease.ConclusionsFewer than half the expected number of patients with retinoblastoma presented to African referral centres in 2017, suggesting poor awareness or other barriers to access. Despite the relatively shorter distance travelled by African patients, they presented with later-stage disease. Health education about retinoblastoma is needed for carers and health workers in Africa in order to increase capture rate and promote early referral. | |
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| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t The British journal of ophthalmologyd : BMJg 105:10, s. 1435-1443q 105:10<1435-1443x 1468-2079x 0007-1161 |
| 856 | 4 | u https://usiena-air.unisi.it/bitstream/11365/1121741/1/Travel%20burden%20and%20clinical%20presentation%20of%20retinoblastoma-bjophthalmol-2020.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:147696770 |
| 856 | 4 8 | u https://doi.org/10.1136/bjophthalmol-2020-316613 |
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