Search: onr:"swepub:oai:prod.swepub.kib.ki.se:147860383" >
Interobserver Agree...
-
Van Bockstal, MR
(author)
Interobserver Agreement of PD-L1/SP142 Immunohistochemistry and Tumor-Infiltrating Lymphocytes (TILs) in Distant Metastases of Triple-Negative Breast Cancer: A Proof-of-Concept Study. A Report on Behalf of the International Immuno-Oncology Biomarker Working Group
- Article/chapterEnglish2021
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:147860383
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:147860383URI
-
https://doi.org/10.3390/cancers13194910DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Patients with advanced triple-negative breast cancer (TNBC) benefit from treatment with atezolizumab, provided that the tumor contains ≥1% of PD-L1/SP142-positive immune cells. Numbers of tumor-infiltrating lymphocytes (TILs) vary strongly according to the anatomic localization of TNBC metastases. We investigated inter-pathologist agreement in the assessment of PD-L1/SP142 immunohistochemistry and TILs. Ten pathologists evaluated PD-L1/SP142 expression in a proficiency test comprising 28 primary TNBCs, as well as PD-L1/SP142 expression and levels of TILs in 49 distant TNBC metastases with various localizations. Interobserver agreement for PD-L1 status (positive vs. negative) was high in the proficiency test: the corresponding scores as percentages showed good agreement with the consensus diagnosis. In TNBC metastases, there was substantial variability in PD-L1 status at the individual patient level. For one in five patients, the chance of treatment was essentially random, with half of the pathologists designating them as positive and half negative. Assessment of PD-L1/SP142 and TILs as percentages in TNBC metastases showed poor and moderate agreement, respectively. Additional training for metastatic TNBC is required to enhance interobserver agreement. Such training, focusing on metastatic specimens, seems worthwhile, since the same pathologists obtained high percentages of concordance (ranging from 93% to 100%) on the PD-L1 status of primary TNBCs.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Cooks, M
(author)
-
Nederlof, I
(author)
-
Brinkhuis, M
(author)
-
Dutman, A
(author)
-
Koopmans, M
(author)
-
Kooreman, L
(author)
-
van der Vegt, B
(author)
-
Verhoog, L
(author)
-
Vreuls, C
(author)
-
Westenend, P
(author)
-
Kok, M
(author)
-
van Diest, PJ
(author)
-
Nauwelaers, I
(author)
-
Laudus, N
(author)
-
Denkert, C
(author)
-
Rimm, D
(author)
-
Siziopikou, KP
(author)
-
Ely, S
(author)
-
Zardavas, D
(author)
-
Roberts, M
(author)
-
Floris, G
(author)
-
Hartman, JKarolinska Institutet
(author)
-
Acs, BKarolinska Institutet
(author)
-
Peeters, D
(author)
-
Bartlett, JMS
(author)
-
Dequeker, E
(author)
-
Salgado, R
(author)
-
Giudici, F
(author)
-
Michiels, S
(author)
-
Horlings, H
(author)
-
van Deurzen, CHM
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:Cancers: MDPI AG13:192072-6694
Internet link
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Van Bockstal, MR
-
Cooks, M
-
Nederlof, I
-
Brinkhuis, M
-
Dutman, A
-
Koopmans, M
-
show more...
-
Kooreman, L
-
van der Vegt, B
-
Verhoog, L
-
Vreuls, C
-
Westenend, P
-
Kok, M
-
van Diest, PJ
-
Nauwelaers, I
-
Laudus, N
-
Denkert, C
-
Rimm, D
-
Siziopikou, KP
-
Ely, S
-
Zardavas, D
-
Roberts, M
-
Floris, G
-
Hartman, J
-
Acs, B
-
Peeters, D
-
Bartlett, JMS
-
Dequeker, E
-
Salgado, R
-
Giudici, F
-
Michiels, S
-
Horlings, H
-
van Deurzen, CHM
-
show less...
- Articles in the publication
-
Cancers
- By the university
-
Karolinska Institutet