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A multimodal cell c...
A multimodal cell census and atlas of the mammalian primary motor cortex
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-10-06
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Springer Science and Business Media LLC,2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:147890569
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147890569URI
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https://doi.org/10.1038/s41586-021-03950-0DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
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Dong, HW
(author)
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Ecker, JR
(author)
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Hawrylycz, MJ
(author)
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Huang, ZJ
(author)
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Lein, ES
(author)
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Ngai, J
(author)
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Osten, P
(author)
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Ren, B
(author)
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Tolias, AS
(author)
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White, O
(author)
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Zeng, HK
(author)
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Zhuang, XW
(author)
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Ascoli, GA
(author)
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Behrens, MM
(author)
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Chun, J
(author)
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Feng, GP
(author)
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Gee, JC
(author)
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Ghosh, SS
(author)
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Halchenko, YO
(author)
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Hertzano, R
(author)
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Lim, BK
(author)
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Martone, ME
(author)
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Ng, L
(author)
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Pachter, L
(author)
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Ropelewski, AJ
(author)
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Tickle, TL
(author)
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Yang, XW
(author)
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Zhang, K
(author)
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Bakken, TE
(author)
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Berens, P
(author)
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Daigle, TL
(author)
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Harris, JA
(author)
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Jorstad, NL
(author)
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Kalmbach, BE
(author)
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Kobak, D
(author)
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Li, YE
(author)
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Liu, HQ
(author)
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Matho, KS
(author)
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Mukamel, EA
(author)
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Naeemi, M
(author)
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Scala, F
(author)
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Tan, PC
(author)
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Ting, JT
(author)
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Xie, FM
(author)
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Zhang, M
(author)
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Zhang, ZZ
(author)
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Zhou, JT
(author)
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Zingg, B
(author)
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Bertagnolli, D
(author)
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Casper, T
(author)
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Crichton, K
(author)
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Dee, N
(author)
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Diep, D
(author)
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Ding, SL
(author)
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Dong, WX
(author)
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Dougherty, EL
(author)
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Fong, O
(author)
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Goldman, M
(author)
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Goldy, J
(author)
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Hodge, RD
(author)
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Hu, LJ
(author)
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Keene, CD
(author)
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Krienen, FM
(author)
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Kroll, M
(author)
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Lake, BB
(author)
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Lathia, K
(author)
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Linnarsson, SKarolinska Institutet
(author)
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Liu, CS
(author)
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Macosko, EZ
(author)
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McCarroll, SA
(author)
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McMillen, D
(author)
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Nadaf, NM
(author)
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Nguyen, TN
(author)
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Palmer, CR
(author)
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Pham, T
(author)
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Plongthongkum, N
(author)
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Reed, NM
(author)
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Regev, A
(author)
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Rimorin, C
(author)
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Romanow, WJ
(author)
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Savoia, S
(author)
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Siletti, K
(author)
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Smith, K
(author)
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Sulc, J
(author)
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Tasic, B
(author)
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Tieu, M
(author)
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Torkelson, A
(author)
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Tung, H
(author)
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van Velthoven, CTJ
(author)
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Vanderburg, CR
(author)
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Yanny, AM
(author)
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Fang, RX
(author)
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Hou, XM
(author)
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Lucero, JD
(author)
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Osteen, JK
(author)
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Pinto-Duarte, A
(author)
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Poirion, O
(author)
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Preissl, S
(author)
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Wang, XX
(author)
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Aldridge, AI
(author)
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Bartlett, A
(author)
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Boggeman, L
(author)
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O'Connor, C
(author)
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Castanon, RG
(author)
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Chen, HM
(author)
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Fitzpatrick, C
(author)
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Luo, CY
(author)
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Nery, JR
(author)
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Nunn, M
(author)
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Rivkin, AC
(author)
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Tian, W
(author)
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Dominguez, B
(author)
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Ito-Cole, T
(author)
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Jacobs, M
(author)
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Jin, X
(author)
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Lee, CT
(author)
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Lee, KF
(author)
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Miyazaki, PA
(author)
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Pang, Y
(author)
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Rashid, M
(author)
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Smith, JB
(author)
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Vu, M
(author)
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Williams, E
(author)
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Armand, E
(author)
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Biancalani, T
(author)
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Booeshaghi, AS
(author)
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Crow, M
(author)
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Dudoit, S
(author)
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Fischer, S
(author)
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Gillis, J
(author)
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Hu, QW
(author)
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Kharchenko, PV
(author)
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Niu, SY
(author)
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Ntranos, V
(author)
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Purdom, E
(author)
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Risso, D
(author)
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de Bezieux, HR
(author)
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Somasundaram, S
(author)
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Street, K
(author)
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Svensson, V
(author)
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Vaishnav, ED
(author)
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Van den Berge, K
(author)
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Welch, JD
(author)
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Yao, ZZ
(author)
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An, X
(author)
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Bateup, HS
(author)
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Bowman, I
(author)
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Chance, RK
(author)
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Foster, NN
(author)
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Galbavy, W
(author)
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Gong, H
(author)
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Gou, L
(author)
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Hatfield, JT
(author)
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Hintiryan, H
(author)
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Hirokawa, KE
(author)
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Kim, G
(author)
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Kramer, DJ
(author)
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Li, AA
(author)
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Li, XN
(author)
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Luo, QM
(author)
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Munoz-Castaneda, R
(author)
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Stafford, DA
(author)
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Feng, Z
(author)
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Jia, XY
(author)
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Jiang, SD
(author)
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Jiang, T
(author)
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Kuang, XL
(author)
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Larsen, R
(author)
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Lesnar, P
(author)
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Li, YY
(author)
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Li, YY
(author)
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Liu, LJ
(author)
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Peng, HC
(author)
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Qu, L
(author)
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Ren, M
(author)
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Ruan, ZC
(author)
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Shen, E
(author)
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Song, YY
(author)
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Wakeman, W
(author)
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Wang, P
(author)
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Wang, YM
(author)
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Wang, Y
(author)
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Yin, LL
(author)
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Yuan, J
(author)
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Zhao, SJ
(author)
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Zhao, X
(author)
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Narasimhan, A
(author)
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Palaniswamy, R
(author)
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Banerjee, S
(author)
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Ding, LY
(author)
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Huilgol, D
(author)
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Huo, BX
(author)
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Kuo, HC
(author)
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Laturnus, S
(author)
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Li, X
(author)
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Mitra, PP
(author)
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Mizrachi, J
(author)
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Wang, QX
(author)
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Xie, P
(author)
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Xiong, F
(author)
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Yu, Y
(author)
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Eichhorn, SW
(author)
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Berg, J
(author)
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Bernabucci, M
(author)
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Bernaerts, Y
(author)
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Cadwell, CR
(author)
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Castro, JR
(author)
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Dalley, R
(author)
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Hartmanis, LKarolinska Institutet
(author)
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Horwitz, GD
(author)
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Jiang, XL
(author)
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Ko, AL
(author)
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Miranda, E
(author)
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Mulherkar, S
(author)
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Nicovich, PR
(author)
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Owen, SF
(author)
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Sandberg, RKarolinska Institutet
(author)
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Sorensen, SA
(author)
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Tan, ZH
(author)
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Allen, S
(author)
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Hockemeyer, D
(author)
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Lee, AY
(author)
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Veldman, MB
(author)
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Adkins, RS
(author)
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Ament, SA
(author)
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Bravo, HC
(author)
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Carter, R
(author)
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Chatterjee, A
(author)
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Colantuoni, C
(author)
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Crabtree, J
(author)
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Creasy, H
(author)
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Felix, V
(author)
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Giglio, M
(author)
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Herb, BR
(author)
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Kancherla, J
(author)
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Mahurkar, A
(author)
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McCracken, C
(author)
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Nickel, L
(author)
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Olley, D
(author)
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Orvis, J
(author)
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Schor, M
(author)
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Hood, G
(author)
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Dichter, B
(author)
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Grauer, M
(author)
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Helba, B
(author)
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Bandrowski, A
(author)
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Barkas, N
(author)
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Carlin, B
(author)
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D'Orazi, FD
(author)
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Degatano, K
(author)
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Gillespie, TH
(author)
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Khajouei, F
(author)
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Konwar, K
(author)
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Thompson, C
(author)
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Kelly, K
(author)
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Mok, S
(author)
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Sunkin, S
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature: Springer Science and Business Media LLC598:7879, s. 86-1021476-46870028-0836
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- By the author/editor
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Callaway, EM
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Dong, HW
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Ecker, JR
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Hawrylycz, MJ
-
Huang, ZJ
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Lein, ES
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show more...
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Ngai, J
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Osten, P
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Ren, B
-
Tolias, AS
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White, O
-
Zeng, HK
-
Zhuang, XW
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Ascoli, GA
-
Behrens, MM
-
Chun, J
-
Feng, GP
-
Gee, JC
-
Ghosh, SS
-
Halchenko, YO
-
Hertzano, R
-
Lim, BK
-
Martone, ME
-
Ng, L
-
Pachter, L
-
Ropelewski, AJ
-
Tickle, TL
-
Yang, XW
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Zhang, K
-
Bakken, TE
-
Berens, P
-
Daigle, TL
-
Harris, JA
-
Jorstad, NL
-
Kalmbach, BE
-
Kobak, D
-
Li, YE
-
Liu, HQ
-
Matho, KS
-
Mukamel, EA
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Naeemi, M
-
Scala, F
-
Tan, PC
-
Ting, JT
-
Xie, FM
-
Zhang, M
-
Zhang, ZZ
-
Zhou, JT
-
Zingg, B
-
Bertagnolli, D
-
Casper, T
-
Crichton, K
-
Dee, N
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Diep, D
-
Ding, SL
-
Dong, WX
-
Dougherty, EL
-
Fong, O
-
Goldman, M
-
Goldy, J
-
Hodge, RD
-
Hu, LJ
-
Keene, CD
-
Krienen, FM
-
Kroll, M
-
Lake, BB
-
Lathia, K
-
Linnarsson, S
-
Liu, CS
-
Macosko, EZ
-
McCarroll, SA
-
McMillen, D
-
Nadaf, NM
-
Nguyen, TN
-
Palmer, CR
-
Pham, T
-
Plongthongkum, N
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Reed, NM
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Regev, A
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Rimorin, C
-
Romanow, WJ
-
Savoia, S
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Siletti, K
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Smith, K
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Sulc, J
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Tasic, B
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Tieu, M
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Torkelson, A
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Tung, H
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van Velthoven, C ...
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Vanderburg, CR
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Yanny, AM
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Fang, RX
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Hou, XM
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Lucero, JD
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Osteen, JK
-
Pinto-Duarte, A
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Poirion, O
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Preissl, S
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Wang, XX
-
Aldridge, AI
-
Bartlett, A
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Boggeman, L
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O'Connor, C
-
Castanon, RG
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Chen, HM
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Fitzpatrick, C
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Luo, CY
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Nery, JR
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Nunn, M
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Rivkin, AC
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Tian, W
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Dominguez, B
-
Ito-Cole, T
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Jacobs, M
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Jin, X
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Lee, CT
-
Lee, KF
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Miyazaki, PA
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Pang, Y
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Rashid, M
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Smith, JB
-
Vu, M
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Williams, E
-
Armand, E
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Biancalani, T
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Booeshaghi, AS
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Crow, M
-
Dudoit, S
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Fischer, S
-
Gillis, J
-
Hu, QW
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Kharchenko, PV
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Niu, SY
-
Ntranos, V
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Purdom, E
-
Risso, D
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de Bezieux, HR
-
Somasundaram, S
-
Street, K
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Svensson, V
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Vaishnav, ED
-
Van den Berge, K
-
Welch, JD
-
Yao, ZZ
-
An, X
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Bateup, HS
-
Bowman, I
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Chance, RK
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Foster, NN
-
Galbavy, W
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Gong, H
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Gou, L
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Hatfield, JT
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Hintiryan, H
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Hirokawa, KE
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Kim, G
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Kramer, DJ
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Li, AA
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Li, XN
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Luo, QM
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Munoz-Castaneda, ...
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Stafford, DA
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Feng, Z
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Jia, XY
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Jiang, SD
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Jiang, T
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Kuang, XL
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Larsen, R
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Lesnar, P
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Li, YY
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Liu, LJ
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Peng, HC
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Qu, L
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Ren, M
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Ruan, ZC
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Shen, E
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Song, YY
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Wakeman, W
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Wang, P
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Wang, YM
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Wang, Y
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Yin, LL
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Yuan, J
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Zhao, SJ
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Zhao, X
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Narasimhan, A
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Palaniswamy, R
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Banerjee, S
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Ding, LY
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Huilgol, D
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Huo, BX
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Kuo, HC
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Laturnus, S
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Li, X
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Mitra, PP
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Mizrachi, J
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Wang, QX
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Xie, P
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Xiong, F
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Yu, Y
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Eichhorn, SW
-
Berg, J
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Bernabucci, M
-
Bernaerts, Y
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Cadwell, CR
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Castro, JR
-
Dalley, R
-
Hartmanis, L
-
Horwitz, GD
-
Jiang, XL
-
Ko, AL
-
Miranda, E
-
Mulherkar, S
-
Nicovich, PR
-
Owen, SF
-
Sandberg, R
-
Sorensen, SA
-
Tan, ZH
-
Allen, S
-
Hockemeyer, D
-
Lee, AY
-
Veldman, MB
-
Adkins, RS
-
Ament, SA
-
Bravo, HC
-
Carter, R
-
Chatterjee, A
-
Colantuoni, C
-
Crabtree, J
-
Creasy, H
-
Felix, V
-
Giglio, M
-
Herb, BR
-
Kancherla, J
-
Mahurkar, A
-
McCracken, C
-
Nickel, L
-
Olley, D
-
Orvis, J
-
Schor, M
-
Hood, G
-
Dichter, B
-
Grauer, M
-
Helba, B
-
Bandrowski, A
-
Barkas, N
-
Carlin, B
-
D'Orazi, FD
-
Degatano, K
-
Gillespie, TH
-
Khajouei, F
-
Konwar, K
-
Thompson, C
-
Kelly, K
-
Mok, S
-
Sunkin, S
-
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