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Preferential and pe...
Preferential and persistent impact of acute HIV-1 infection on CD4+ iNKT cells in colonic mucosa
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Paquin-Proulx, D (author)
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Lal, KG (author)
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Phuang-Ngern, Y (author)
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Creegan, M (author)
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Tokarev, A (author)
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Suhkumvittaya, S (author)
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Alrubayyi, A (author)
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Kroon, E (author)
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Pinyakorn, S (author)
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Slike, BM (author)
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Bolton, DL (author)
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Krebs, SJ (author)
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Eller, LA (author)
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Sajjaweerawan, C (author)
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Pagliuzza, A (author)
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Chomont, N (author)
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Rerknimitr, R (author)
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Chomchey, N (author)
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Phanuphak, N (author)
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de Souza, MS (author)
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Michael, NL (author)
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Robb, ML (author)
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Ananworanich, J (author)
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- Sandberg, JK (author)
- Karolinska Institutet
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Eller, MA (author)
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Schuetz, A (author)
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(creator_code:org_t)
- 2021-11-09
- 2021
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 118:46
- Related links:
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https://www.pnas.org...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Evidence suggests that HIV-1 disease progression is determined in the early stages of infection. Here, preinfection invariant natural killer T (iNKT) cell levels were predictive of the peak viral load during acute HIV-1 infection (AHI). Furthermore, iNKT cells were preferentially lost in AHI. This was particularly striking in the colonic mucosa, where iNKT cells were depleted more profoundly than conventional CD4+T cells. The initiation of antiretroviral therapy during AHI-prevented iNKT cell dysregulation in peripheral blood but not in the colonic mucosa. Overall, our results support a model in which iNKT cells are early and preferential targets for HIV-1 infection during AHI.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Paquin-Proulx, D
-
Lal, KG
-
Phuang-Ngern, Y
-
Creegan, M
-
Tokarev, A
-
Suhkumvittaya, S
-
show more...
-
Alrubayyi, A
-
Kroon, E
-
Pinyakorn, S
-
Slike, BM
-
Bolton, DL
-
Krebs, SJ
-
Eller, LA
-
Sajjaweerawan, C
-
Pagliuzza, A
-
Chomont, N
-
Rerknimitr, R
-
Chomchey, N
-
Phanuphak, N
-
de Souza, MS
-
Michael, NL
-
Robb, ML
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Ananworanich, J
-
Sandberg, JK
-
Eller, MA
-
Schuetz, A
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show less...
- Articles in the publication
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Proceedings of t ...
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Proceedings of t ...
- By the university
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Karolinska Institutet