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Estimation of margi...
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Sjolander, AKarolinska Institutet
(author)
Estimation of marginal causal effects in the presence of confounding by cluster
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2019-12-05
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Oxford University Press (OUP),2021
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:148654330
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148654330URI
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https://doi.org/10.1093/biostatistics/kxz054DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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A popular way to control for unmeasured confounders is to utilize clusters (e.g. sets of siblings), in which a potentially large set of confounders are constant. By estimating the exposure–outcome association within clusters, rather than between unrelated subjects, all cluster-constant confounders are implicitly controlled for. To analyze such clustered data, it is common to use fixed effects models, which absorb all cluster-constant confounders into a cluster-specific intercept. In this article, we show how linear and log-linear fixed effects models can be used to estimate marginal counterfactual means. These counterfactual means can be estimated and presented for each exposure level separately, or contrasted to form a wide range of marginal causal effects. For binary outcomes, we propose to estimate marginal causal effects with marginal logistic between-within models. These models include a constant intercept common for all clusters, and control for unmeasured cluster-constant confounders by adding the mean exposure level in each cluster to the model. We illustrate the proposed methods by re-analyzing data from a co-twin control study on birth weight and Attention-Deficit/Hyperactivity Disorder.
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Biostatistics (Oxford, England): Oxford University Press (OUP)22:3, s. 598-6121468-43571465-4644
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