onr:"swepub:oai:prod.swepub.kib.ki.se:148674847"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:148674847" > Immune persistence ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Immune persistence and response to booster dose of Vi-DT vaccine at 27.5 months post-first dose
- Capeding, MR (author)
-
- Tadesse, BT (author)
- Karolinska Institutet
- Sil, A (author)
- show more...
- Alberto, E (author)
- Kim, DR (author)
- Park, EL (author)
- Park, JY (author)
- Yang, JS (author)
- Eluru, JR (author)
- Jo, SK (author)
- Kim, H (author)
- Yang, SY (author)
- Ryu, JH (author)
- Park, H (author)
- Shin, JH (author)
- Lee, Y (author)
- Kim, JH (author)
- Mojares, ZR (author)
- Wartel, TA (author)
- Sahastrabuddhe, S (author)
- show less...
- (creator_code:org_t)
- 2022-01-27
- 2022
- English.
- In: NPJ vaccines. - : Springer Science and Business Media LLC. - 2059-0105. ; 7:1, s. 12-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Vaccination with typhoid conjugate vaccines (TCV) is a major part of typhoid prevention. However, little is known about long-term immune persistence following vaccination with TCVs. In this phase-2, randomized double-blind trial (NCT03527355), 285 children aged 6–23 months were randomized to one of three groups: (1) the group that received a first dose of Vi polysaccharide conjugated to diphtheria-toxoid (Vi-DT) vaccine followed by an “early booster” at 24 weeks, (2) the group that which received a first dose of Vi-DT followed by a “late booster” at 96 or 110 weeks, and (3) comparator group. Safety and immunogenicity of anti-Vi IgG GMTs were assessed at weeks 0, 4, 24, 28, 60, 96, 110, and 114 since the first dose. Here, we describe persistence of immune responses at weeks 60, 96, 110, and 114 post first dose. The anti-Vi IgG seroconversion rate after 27.5 months of follow-up was 88.16% (95% CI: 79.00, 93.64) in late-booster and 94.76% (95% CI: 86.91, 97.88) in early booster Vi-DT groups (p = 0.081). Whereas anti-Vi IgG GMTs were significantly higher in the early booster group (11.95 [95% CI: 9.65, 14.81]) than prebooster GMTs in the late booster group (5.50 [95% CI: 4.44, 6.80], p < 0.0001). GMT in the late booster group significantly increased to 351.76 (95% CI: 265.01, 466.93) (p < 0.0001) when measured 4 weeks after they received their “late-booster” shot. In conclusion, late booster dosing with Vi-DT at 27.5 months post first dose was safe and elicited robust anti-Vi IgG immune responses. Anti-Vi IgG seroconversion rates were persistently comparable in early and late-booster Vi-DT groups.
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Capeding, MR
- Tadesse, BT
- Sil, A
- Alberto, E
- Kim, DR
- Park, EL
- show more...
- Park, JY
- Yang, JS
- Eluru, JR
- Jo, SK
- Kim, H
- Yang, SY
- Ryu, JH
- Park, H
- Shin, JH
- Lee, Y
- Kim, JH
- Mojares, ZR
- Wartel, TA
- Sahastrabuddhe, ...
- show less...
- Articles in the publication
- NPJ vaccines
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
