Search: onr:"swepub:oai:prod.swepub.kib.ki.se:148839526" >
Ancestral SARS-CoV-...
Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
-
- Gao, Y (author)
- Karolinska Institutet
-
- Cai, C (author)
- Karolinska Institutet
-
Grifoni, A (author)
-
show more...
-
Muller, TR (author)
-
- Niessl, J (author)
- Karolinska Institutet
-
- Olofsson, A (author)
- Karolinska Institutet
-
- Humbert, M (author)
- Karolinska Institutet
-
- Hansson, L (author)
- Karolinska Institutet
-
- Osterborg, A (author)
- Karolinska Institutet
-
- Bergman, P (author)
- Karolinska Institutet
-
Chen, PR (author)
-
Olsson, A (author)
-
- Sandberg, JK (author)
- Karolinska Institutet
-
Weiskopf, D (author)
-
Price, DA (author)
-
- Ljunggren, HG (author)
- Karolinska Institutet
-
- Karlsson, AC (author)
- Karolinska Institutet
-
Sette, A (author)
-
- Aleman, S (author)
- Karolinska Institutet
-
- Buggert, M (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2022-01-14
- 2022
- English.
-
In: Nature medicine. - : Springer Science and Business Media LLC. - 1546-170X .- 1078-8956. ; 28:3, s. 472-
- Related links:
-
https://www.nature.c...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant of concern (VOC) has destabilized global efforts to control the impact of coronavirus disease 2019 (COVID-19). Recent data have suggested that B.1.1.529 can readily infect people with naturally acquired or vaccine-induced immunity, facilitated in some cases by viral escape from antibodies that neutralize ancestral SARS-CoV-2. However, severe disease appears to be relatively uncommon in such individuals, highlighting a potential role for other components of the adaptive immune system. We report here that SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against B.1.1.529. The median relative frequencies of SARS-CoV-2 spike-specific CD4+ T cells that cross-recognized B.1.1.529 in previously infected or BNT162b2-vaccinated individuals were 84% and 91%, respectively, and the corresponding median relative frequencies for SARS-CoV-2 spike-specific CD8+ T cells were 70% and 92%, respectively. Pairwise comparisons across groups further revealed that SARS-CoV-2 spike-reactive CD4+ and CD8+ T cells were functionally and phenotypically similar in response to the ancestral strain or B.1.1.529. Collectively, our data indicate that established SARS-CoV-2 spike-specific CD4+ and CD8+ T cell responses, especially after BNT162b2 vaccination, remain largely intact against B.1.1.529.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gao, Y
-
Cai, C
-
Grifoni, A
-
Muller, TR
-
Niessl, J
-
Olofsson, A
-
show more...
-
Humbert, M
-
Hansson, L
-
Osterborg, A
-
Bergman, P
-
Chen, PR
-
Olsson, A
-
Sandberg, JK
-
Weiskopf, D
-
Price, DA
-
Ljunggren, HG
-
Karlsson, AC
-
Sette, A
-
Aleman, S
-
Buggert, M
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
- Articles in the publication
-
Nature medicine
- By the university
-
Karolinska Institutet