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A polygenic risk sc...
A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
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He, YQ (author)
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Wang, TM (author)
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Ji, MF (author)
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show more...
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Mai, ZM (author)
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Tang, MZ (author)
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Wang, RZ (author)
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Zhou, YF (author)
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Zheng, YM (author)
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Xiao, RW (author)
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Yang, DW (author)
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Wu, ZY (author)
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Deng, CM (author)
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Zhang, JB (author)
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Xue, WQ (author)
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Dong, SQ (author)
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Zhan, JY (author)
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Cai, YL (author)
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Li, FG (author)
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Wu, BH (author)
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Liao, Y (author)
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Zhou, T (author)
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Zheng, MQ (author)
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Jia, YJ (author)
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Li, DH (author)
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Cao, LJ (author)
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Yuan, LL (author)
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Zhang, WL (author)
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Luo, LT (author)
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Tong, XT (author)
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Wu, YX (author)
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Li, XZ (author)
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Zhang, PF (author)
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Zheng, XH (author)
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Zhang, SD (author)
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Hu, YZ (author)
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Qin, WL (author)
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Deng, BS (author)
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Liang, XJ (author)
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Fan, PW (author)
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Feng, YN (author)
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Song, J (author)
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Xie, SH (author)
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Chang, ET (author)
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Zhang, Z (author)
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Huang, GW (author)
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Xu, M (author)
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Feng, L (author)
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Jin, GF (author)
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Bei, JX (author)
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Cao, SM (author)
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Liu, Q (author)
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Kozlakidis, ZS (author)
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Mai, HQ (author)
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Sun, Y (author)
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Ma, J (author)
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Hu, ZB (author)
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Liu, JJ (author)
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Lung, ML (author)
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- Adami, HO (author)
- Karolinska Institutet
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Shen, HB (author)
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- Ye, WM (author)
- Karolinska Institutet
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Lam, T (author)
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Zeng, YX (author)
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Jia, WH (author)
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(creator_code:org_t)
- 2022-04-12
- 2022
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 1966-
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https://doi.org/10.1...
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Abstract
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- Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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He, YQ
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Wang, TM
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Ji, MF
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Mai, ZM
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Tang, MZ
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Wang, RZ
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show more...
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Zhou, YF
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Zheng, YM
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Xiao, RW
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Yang, DW
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Wu, ZY
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Deng, CM
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Zhang, JB
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Xue, WQ
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Dong, SQ
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Zhan, JY
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Cai, YL
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Li, FG
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Wu, BH
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Liao, Y
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Zhou, T
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Zheng, MQ
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Jia, YJ
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Li, DH
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Cao, LJ
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Yuan, LL
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Zhang, WL
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Luo, LT
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Tong, XT
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Wu, YX
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Li, XZ
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Zhang, PF
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Zheng, XH
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Zhang, SD
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Hu, YZ
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Qin, WL
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Deng, BS
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Liang, XJ
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Fan, PW
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Feng, YN
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Song, J
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Xie, SH
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Chang, ET
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Zhang, Z
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Huang, GW
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Xu, M
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Feng, L
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Jin, GF
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Bei, JX
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Cao, SM
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Liu, Q
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Kozlakidis, ZS
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Mai, HQ
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Sun, Y
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Ma, J
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Hu, ZB
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Liu, JJ
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Lung, ML
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Adami, HO
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Shen, HB
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Ye, WM
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Lam, T
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Zeng, YX
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Jia, WH
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet