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  • He, YQ (author)

A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-04-12
  • Springer Science and Business Media LLC,2022

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:149285914
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149285914URI
  • https://doi.org/10.1038/s41467-022-29570-4DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Wang, TM (author)
  • Ji, MF (author)
  • Mai, ZM (author)
  • Tang, MZ (author)
  • Wang, RZ (author)
  • Zhou, YF (author)
  • Zheng, YM (author)
  • Xiao, RW (author)
  • Yang, DW (author)
  • Wu, ZY (author)
  • Deng, CM (author)
  • Zhang, JB (author)
  • Xue, WQ (author)
  • Dong, SQ (author)
  • Zhan, JY (author)
  • Cai, YL (author)
  • Li, FG (author)
  • Wu, BH (author)
  • Liao, Y (author)
  • Zhou, T (author)
  • Zheng, MQ (author)
  • Jia, YJ (author)
  • Li, DH (author)
  • Cao, LJ (author)
  • Yuan, LL (author)
  • Zhang, WL (author)
  • Luo, LT (author)
  • Tong, XT (author)
  • Wu, YX (author)
  • Li, XZ (author)
  • Zhang, PF (author)
  • Zheng, XH (author)
  • Zhang, SD (author)
  • Hu, YZ (author)
  • Qin, WL (author)
  • Deng, BS (author)
  • Liang, XJ (author)
  • Fan, PW (author)
  • Feng, YN (author)
  • Song, J (author)
  • Xie, SH (author)
  • Chang, ET (author)
  • Zhang, Z (author)
  • Huang, GW (author)
  • Xu, M (author)
  • Feng, L (author)
  • Jin, GF (author)
  • Bei, JX (author)
  • Cao, SM (author)
  • Liu, Q (author)
  • Kozlakidis, ZS (author)
  • Mai, HQ (author)
  • Sun, Y (author)
  • Ma, J (author)
  • Hu, ZB (author)
  • Liu, JJ (author)
  • Lung, ML (author)
  • Adami, HOKarolinska Institutet (author)
  • Shen, HB (author)
  • Ye, WMKarolinska Institutet (author)
  • Lam, T (author)
  • Zeng, YX (author)
  • Jia, WH (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Nature communications: Springer Science and Business Media LLC13:1, s. 1966-2041-1723

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