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A polygenic risk sc...
A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-04-12
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149285914
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149285914URI
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https://doi.org/10.1038/s41467-022-29570-4DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Polygenic risk scores (PRS) have the potential to identify individuals at risk of diseases, optimizing treatment, and predicting survival outcomes. Here, we construct and validate a genome-wide association study (GWAS) derived PRS for nasopharyngeal carcinoma (NPC), using a multi-center study of six populations (6 059 NPC cases and 7 582 controls), and evaluate its utility in a nested case-control study. We show that the PRS enables effective identification of NPC high-risk individuals (AUC = 0.65) and improves the risk prediction with the PRS incremental deciles in each population (Ptrend ranging from 2.79 × 10−7 to 4.79 × 10−44). By incorporating the PRS into EBV-serology-based NPC screening, the test’s positive predictive value (PPV) is increased from an average of 4.84% to 8.38% and 11.91% in the top 10% and 5% PRS, respectively. In summary, the GWAS-derived PRS, together with the EBV test, significantly improves NPC risk stratification and informs personalized screening.
Added entries (persons, corporate bodies, meetings, titles ...)
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Wang, TM
(author)
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Ji, MF
(author)
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Mai, ZM
(author)
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Tang, MZ
(author)
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Wang, RZ
(author)
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Zhou, YF
(author)
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Zheng, YM
(author)
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Xiao, RW
(author)
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Yang, DW
(author)
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Wu, ZY
(author)
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Deng, CM
(author)
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Zhang, JB
(author)
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Xue, WQ
(author)
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Dong, SQ
(author)
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Zhan, JY
(author)
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Cai, YL
(author)
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Li, FG
(author)
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Wu, BH
(author)
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Liao, Y
(author)
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Zhou, T
(author)
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Zheng, MQ
(author)
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Jia, YJ
(author)
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Li, DH
(author)
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Cao, LJ
(author)
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Yuan, LL
(author)
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Zhang, WL
(author)
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Luo, LT
(author)
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Tong, XT
(author)
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Wu, YX
(author)
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Li, XZ
(author)
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Zhang, PF
(author)
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Zheng, XH
(author)
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Zhang, SD
(author)
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Hu, YZ
(author)
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Qin, WL
(author)
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Deng, BS
(author)
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Liang, XJ
(author)
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Fan, PW
(author)
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Feng, YN
(author)
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Song, J
(author)
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Xie, SH
(author)
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Chang, ET
(author)
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Zhang, Z
(author)
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Huang, GW
(author)
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Xu, M
(author)
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Feng, L
(author)
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Jin, GF
(author)
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Bei, JX
(author)
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Cao, SM
(author)
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Liu, Q
(author)
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Kozlakidis, ZS
(author)
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Mai, HQ
(author)
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Sun, Y
(author)
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Ma, J
(author)
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Hu, ZB
(author)
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Liu, JJ
(author)
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Lung, ML
(author)
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Adami, HOKarolinska Institutet
(author)
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Shen, HB
(author)
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Ye, WMKarolinska Institutet
(author)
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Lam, T
(author)
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Zeng, YX
(author)
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Jia, WH
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC13:1, s. 1966-2041-1723
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- By the author/editor
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He, YQ
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Wang, TM
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Ji, MF
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Mai, ZM
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Tang, MZ
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Wang, RZ
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show more...
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Zhou, YF
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Zheng, YM
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Xiao, RW
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Yang, DW
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Wu, ZY
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Deng, CM
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Zhang, JB
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Xue, WQ
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Dong, SQ
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Zhan, JY
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Cai, YL
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Li, FG
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Wu, BH
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Liao, Y
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Zhou, T
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Zheng, MQ
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Jia, YJ
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Li, DH
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Cao, LJ
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Yuan, LL
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Zhang, WL
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Luo, LT
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Tong, XT
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Wu, YX
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Li, XZ
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Zhang, PF
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Zheng, XH
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Zhang, SD
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Hu, YZ
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Qin, WL
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Deng, BS
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Liang, XJ
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Fan, PW
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Feng, YN
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Song, J
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Xie, SH
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Chang, ET
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Zhang, Z
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Huang, GW
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Xu, M
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Feng, L
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Jin, GF
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Bei, JX
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Cao, SM
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Liu, Q
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Kozlakidis, ZS
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Mai, HQ
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Sun, Y
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Ma, J
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Hu, ZB
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Liu, JJ
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Lung, ML
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Adami, HO
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Shen, HB
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Ye, WM
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Lam, T
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Zeng, YX
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Jia, WH
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Nature communica ...
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Karolinska Institutet