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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003213naa a2200373 4500
001oai:prod.swepub.kib.ki.se:149362581
003SwePub
008240811s2022 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1493625812 URI
0247 a https://doi.org/10.3389/fimmu.2022.8424512 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dijkstra, DJ4 aut
2451 0a Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia
264 c 2022-03-31
264 1b Frontiers Media SA,c 2022
520 a Preeclampsia (PE) generally manifests in the second half of pregnancy with hypertension and proteinuria. The understanding of the origin and mechanism behind PE is incomplete, although there is clearly an immune component to this disorder. The placenta constitutes a complicated immune interface between fetal and maternal cells, where regulation and tolerance are key. Stress factors from placental dysfunction in PE are released to the maternal circulation evoking the maternal response. Several complement factors play a role within this intricate landscape, including C1q in vascular remodeling and Factor H (FH) as the key regulator of alternative pathway complement activation. We hypothesize that decreased levels of C1q or FH, or disturbance of their function by autoantibodies, may be associated with PE. Autoantibodies against C1q and FH and the concentrations of C1q and FH were measured by ELISA in maternal sera from women with preeclamptic and normal pregnancies. Samples originated from cohorts collected in the Netherlands (n=63 PE; n=174 control pregnancies, n=51 nonpregnant), Finland (n=181 PE; n=63 control pregnancies) and Norway (n=59 PE; n=27 control pregnancies). Serum C1q and FH concentrations were higher in control pregnancy than in nonpregnant women. No significant differences were observed for serum C1q between preeclamptic and control pregnancy in any of the three cohorts. Serum levels of FH were lower in preeclamptic pregnancies compared to control pregnancies in two of the cohorts, this effect was driven by the early onset PE cases. Neither anti-C1q autoantibodies nor anti-FH autoantibodies levels differed between women with PE and normal pregnancies. In conclusion, levels of anti-C1q and anti-FH autoantibodies are not increased in PE. C1q and FH are increased in pregnancy, but importantly, a decrease in FH concentration is associated with PE.
7001 a Lokki, AI4 aut
7001 a Gierman, LM4 aut
7001 a Borggreven, NV4 aut
7001 a van der Keur, C4 aut
7001 a Eikmans, M4 aut
7001 a Gelderman, KA4 aut
7001 a Laivuori, H4 aut
7001 a Grp, ACFCI4 aut
7001 a Iversen, AC4 aut
7001 a van der Hoorn, MLP4 aut
7001 a Trouw, LA4 aut
7730 t Frontiers in immunologyd : Frontiers Media SAg 13, s. 842451-q 13<842451-x 1664-3224
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149362581
8564 8u https://doi.org/10.3389/fimmu.2022.842451

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