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Oxime derivative TF...
Oxime derivative TFOBO promotes cell death by modulating reactive oxygen species and regulating NADPH oxidase activity in myeloid leukemia
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-05-07
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149527611
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149527611URI
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https://doi.org/10.1038/s41598-022-11543-8DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Several derivatives derived from the oxime structure have been reported as potential anticancer agents in various cancers. Here, we first tested a novel oxime-containing derivative of 2-((2,4,5-trifluorobenzyl)oxy)benzaldehyde oxime (TFOBO) to evaluate its anticancer effect in myeloid leukemic cells. Compared to (2-((2,4,5-trifluorobenzyl)oxy)phenyl)methanol (TFOPM), the oxime derivative TFOBO suppresses leukemic cell growth by significantly increasing reactive oxygen species (ROS) levels and cell death. Leukemic cells treated with TFOBO displayed apoptotic cell death, as indicated by nuclear condensation, DNA fragmentation, and annexin V staining. TFOBO increases Bax/Bcl2 levels, caspase9, and caspase3/7 activity and decreases mitochondrial membrane potential. ROS production was reduced by N-acetyl-l-cysteine, a ROS scavenger, diphenyleneiodonium chloride, a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, after exogenous TFOBO treatment. ROS inhibitors protect leukemic cells from TFOBO-induced cell death. Thus, our study findings suggest that TFOBO promotes apoptosis by modulating ROS and regulating NADPH oxidase activity. Collectively, the oxime-containing derivative TFOBO is a novel therapeutic drug for myeloid leukemia.
Added entries (persons, corporate bodies, meetings, titles ...)
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Kwak, JH
(author)
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Woo, SY
(author)
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Kim, BY
(author)
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Son, Y
(author)
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Choi, HS
(author)
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Kim, J
(author)
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Kwon, M
(author)
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Cho, HR
(author)
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Eo, SK
(author)
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Nam, JH
(author)
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Kim, HS
(author)
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Baryawno, NKarolinska Institutet
(author)
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Lee, D
(author)
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Kim, K
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Scientific reports: Springer Science and Business Media LLC12:1, s. 7519-2045-2322
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Jo, A
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Kwak, JH
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Woo, SY
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Kim, BY
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Son, Y
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Choi, HS
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Kim, J
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Kwon, M
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Cho, HR
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Eo, SK
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Nam, JH
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Kim, HS
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Baryawno, N
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Lee, D
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Kim, K
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Karolinska Institutet