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Arginine Methyltran...
Arginine Methyltransferase PRMT7 Deregulates Expression of RUNX1 Target Genes in T-Cell Acute Lymphoblastic Leukemia
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Oksa, L (author)
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Makinen, A (author)
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Nikkila, A (author)
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Hyvarinen, N (author)
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Laukkanen, S (author)
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Rokka, A (author)
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Haapaniemi, P (author)
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- Seki, M (author)
- Karolinska Institutet
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Takita, J (author)
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Kauko, O (author)
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Heinaniemi, M (author)
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Lohi, O (author)
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(creator_code:org_t)
- 2022-04-26
- 2022
- English.
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In: Cancers. - : MDPI AG. - 2072-6694. ; 14:9
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https://doi.org/10.3...
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Abstract
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- T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with no well-established prognostic biomarkers. We examined the expression of protein arginine methyltransferases across hematological malignancies and discovered high levels of PRMT7 mRNA in T-ALL, particularly in the mature subtypes of T-ALL. The genetic deletion of PRMT7 by CRISPR-Cas9 reduced the colony formation of T-ALL cells and changed arginine monomethylation patterns in protein complexes associated with the RNA and DNA processing and the T-ALL pathogenesis. Among them was RUNX1, whose target gene expression was consequently deregulated. These results suggest that PRMT7 plays an active role in the pathogenesis of T-ALL.
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- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Oksa, L
-
Makinen, A
-
Nikkila, A
-
Hyvarinen, N
-
Laukkanen, S
-
Rokka, A
-
show more...
-
Haapaniemi, P
-
Seki, M
-
Takita, J
-
Kauko, O
-
Heinaniemi, M
-
Lohi, O
-
show less...
- Articles in the publication
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Cancers
- By the university
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Karolinska Institutet