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Complications of Au...
Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
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Waszczuk-Gajda, A (author)
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Penack, O (author)
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Sbianchi, G (author)
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Koster, L (author)
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Blaise, D (author)
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Remenyi, P (author)
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Russell, N (author)
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- Ljungman, P (author)
- Karolinska Institutet
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Trneny, M (author)
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Mayer, J (author)
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Iacobelli, S (author)
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Kobbe, G (author)
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Scheid, C (author)
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Apperley, J (author)
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Touzeau, C (author)
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Lenhoff, S (author)
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Jantunen, E (author)
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Anagnostopoulos, A (author)
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Paris, L (author)
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Browne, P (author)
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Thieblemont, C (author)
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Schaap, N (author)
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Sierra, J (author)
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Yakoub-Agha, I (author)
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Garderet, L (author)
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Styczynski, J (author)
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Schoemans, H (author)
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Moiseev, I (author)
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Duarte, RF (author)
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Peric, Z (author)
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Montoto, S (author)
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van Biezen, A (author)
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Mikulska, M (author)
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Aljurf, M (author)
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Ruutu, T (author)
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Kroger, N (author)
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Morris, C (author)
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Koenecke, C (author)
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Schoenland, S (author)
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Basak, GW (author)
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(creator_code:org_t)
- 2022-06-20
- 2022
- English.
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 11:12
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https://doi.org/10.3...
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Abstract
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- Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0–100 days, 101 days–1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4–108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1–7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3–5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
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- art (subject category)
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- By the author/editor
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Waszczuk-Gajda, ...
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Penack, O
-
Sbianchi, G
-
Koster, L
-
Blaise, D
-
Remenyi, P
-
show more...
-
Russell, N
-
Ljungman, P
-
Trneny, M
-
Mayer, J
-
Iacobelli, S
-
Kobbe, G
-
Scheid, C
-
Apperley, J
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Touzeau, C
-
Lenhoff, S
-
Jantunen, E
-
Anagnostopoulos, ...
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Paris, L
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Browne, P
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Thieblemont, C
-
Schaap, N
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Sierra, J
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Yakoub-Agha, I
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Garderet, L
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Styczynski, J
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Schoemans, H
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Moiseev, I
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Duarte, RF
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Peric, Z
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Montoto, S
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van Biezen, A
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Mikulska, M
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Aljurf, M
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Ruutu, T
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Kroger, N
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Morris, C
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Koenecke, C
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Schoenland, S
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Basak, GW
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show less...
- Articles in the publication
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Journal of clini ...
- By the university
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Karolinska Institutet