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Complications of Au...
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Waszczuk-Gajda, A
(author)
Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study
- Article/chapterEnglish2022
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150043224
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150043224URI
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https://doi.org/10.3390/jcm11123541DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent ≥1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0–100 days, 101 days–1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4–108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1–7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3–5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.
Added entries (persons, corporate bodies, meetings, titles ...)
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Penack, O
(author)
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Sbianchi, G
(author)
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Koster, L
(author)
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Blaise, D
(author)
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Remenyi, P
(author)
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Russell, N
(author)
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Ljungman, PKarolinska Institutet
(author)
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Trneny, M
(author)
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Mayer, J
(author)
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Iacobelli, S
(author)
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Kobbe, G
(author)
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Scheid, C
(author)
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Apperley, J
(author)
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Touzeau, C
(author)
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Lenhoff, S
(author)
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Jantunen, E
(author)
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Anagnostopoulos, A
(author)
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Paris, L
(author)
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Browne, P
(author)
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Thieblemont, C
(author)
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Schaap, N
(author)
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Sierra, J
(author)
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Yakoub-Agha, I
(author)
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Garderet, L
(author)
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Styczynski, J
(author)
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Schoemans, H
(author)
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Moiseev, I
(author)
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Duarte, RF
(author)
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Peric, Z
(author)
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Montoto, S
(author)
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van Biezen, A
(author)
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Mikulska, M
(author)
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Aljurf, M
(author)
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Ruutu, T
(author)
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Kroger, N
(author)
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Morris, C
(author)
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Koenecke, C
(author)
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Schoenland, S
(author)
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Basak, GW
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Journal of clinical medicine: MDPI AG11:122077-0383
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Waszczuk-Gajda, ...
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Penack, O
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Sbianchi, G
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Koster, L
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Blaise, D
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Remenyi, P
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Russell, N
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Ljungman, P
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Trneny, M
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Mayer, J
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Iacobelli, S
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Kobbe, G
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Scheid, C
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Apperley, J
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Touzeau, C
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Lenhoff, S
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Jantunen, E
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Anagnostopoulos, ...
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Paris, L
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Browne, P
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Thieblemont, C
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Schaap, N
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Sierra, J
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Yakoub-Agha, I
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Garderet, L
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Styczynski, J
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Schoemans, H
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Moiseev, I
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Duarte, RF
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Peric, Z
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Montoto, S
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van Biezen, A
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Mikulska, M
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Aljurf, M
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Ruutu, T
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Kroger, N
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Morris, C
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Koenecke, C
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Schoenland, S
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Basak, GW
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