onr:"swepub:oai:prod.swepub.kib.ki.se:150279787"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:150279787" > Vascular Tissue Spe...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Neiburga, KD (author)
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2021-11-12
- MDPI AG,2021
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:150279787
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150279787URI
- https://doi.org/10.3390/biom11111683DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from Arteria mammaria interna (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, p-value (p < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.
Added entries (persons, corporate bodies, meetings, titles ...)
- Vilne, B (author)
- Bauer, S (author)
- Bongiovanni, D (author)
- Ziegler, T (author)
- Lachmann, M (author)
- Wengert, S (author)
- Hawe, JS (author)
- Guldener, U (author)
- Westerlund, AM (author)
- Li, L (author)
- Pang, SC (author)
- Yang, CH (author)
- Saar, K (author)
- Huebner, N (author)
- Maegdefessel, LKarolinska Institutet (author)
- Lange, R (author)
- Krane, M (author)
- Schunkert, H (author)
- von Scheidt, M (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Biomolecules: MDPI AG11:112218-273X
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Neiburga, KD
- Vilne, B
- Bauer, S
- Bongiovanni, D
- Ziegler, T
- Lachmann, M
- show more...
- Wengert, S
- Hawe, JS
- Guldener, U
- Westerlund, AM
- Li, L
- Pang, SC
- Yang, CH
- Saar, K
- Huebner, N
- Maegdefessel, L
- Lange, R
- Krane, M
- Schunkert, H
- von Scheidt, M
- show less...
- Articles in the publication
- Biomolecules
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
