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Bhlhe40 function in...
Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis
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Rauschmeier, R (author)
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- Reinhardt, A (author)
- Karolinska Institutet
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- Gustafsson, C (author)
- Karolinska Institutet
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- Glaros, V (author)
- Karolinska Institutet
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Artemov, AV (author)
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- Dunst, J (author)
- Karolinska Institutet
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Taneja, R (author)
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- Adameyko, I (author)
- Karolinska Institutet
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- Mansson, R (author)
- Karolinska Institutet
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Busslinger, M (author)
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- Kreslavsky, T (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-12-17
- 2021
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 219:2
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https://doi.org/10.1...
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Abstract
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- The generation of high-affinity antibodies against pathogens and vaccines requires the germinal center (GC) reaction, which relies on a complex interplay between specialized effector B and CD4 T lymphocytes, the GC B cells and T follicular helper (TFH) cells. Intriguingly, several positive key regulators of the GC reaction are common for both cell types. Here, we report that the transcription factor Bhlhe40 is a crucial cell-intrinsic negative regulator affecting both the B and T cell sides of the GC reaction. In activated CD4 T cells, Bhlhe40 was required to restrain proliferation, thus limiting the number of TFH cells. In B cells, Bhlhe40 executed its function in the first days after immunization by selectively restricting the generation of the earliest GC B cells but not of early memory B cells or plasmablasts. Bhlhe40-deficient mice with progressing age succumbed to a B cell lymphoma characterized by the accumulation of monoclonal GC B-like cells and polyclonal TFH cells in various tissues.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Rauschmeier, R
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Reinhardt, A
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Gustafsson, C
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Glaros, V
-
Artemov, AV
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Dunst, J
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show more...
-
Taneja, R
-
Adameyko, I
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Mansson, R
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Busslinger, M
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Kreslavsky, T
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet