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IL-10 Overexpressio...
IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection
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Ferreira, CM (author)
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Micheli, C (author)
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Barreira-Silva, P (author)
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Barbosa, AM (author)
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Resende, M (author)
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Vilanova, M (author)
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Silvestre, R (author)
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Cunha, C (author)
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Carvalho, A (author)
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Rodrigues, F (author)
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- Correia-Neves, M (author)
- Karolinska Institutet
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Castro, AG (author)
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Torrado, E (author)
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(creator_code:org_t)
- 2022-07-22
- 2022
- English.
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In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 946181-
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Abstract
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- Control of tuberculosis depends on the rapid expression of protective CD4+ T-cell responses in the Mycobacterium tuberculosis (Mtb)-infected lungs. We have recently shown that the immunomodulatory cytokine IL-10 acts intrinsically in CD4+ T cells and impairs their parenchymal migratory capacity, thereby preventing control of Mtb infection. Herein, we show that IL-10 overexpression does not impact the protection conferred by the established memory CD4+ T-cell response, as BCG-vaccinated mice overexpressing IL-10 only during Mtb infection display an accelerated, BCG-induced, Ag85b-specific CD4+ T-cell response and control Mtb infection. However, IL-10 inhibits the migration of recently activated ESAT-6-specific CD4+ T cells into the lung parenchyma and impairs the development of ectopic lymphoid structures associated with reduced expression of the chemokine receptors CXCR5 and CCR7. Together, our data support a role for BCG vaccination in preventing the immunosuppressive effects of IL-10 in the fast progression of Mtb infection and may provide valuable insights on the mechanisms contributing to the variable efficacy of BCG vaccination.
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- By the author/editor
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Ferreira, CM
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Micheli, C
-
Barreira-Silva, ...
-
Barbosa, AM
-
Resende, M
-
Vilanova, M
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show more...
-
Silvestre, R
-
Cunha, C
-
Carvalho, A
-
Rodrigues, F
-
Correia-Neves, M
-
Castro, AG
-
Torrado, E
-
show less...
- Articles in the publication
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Frontiers in imm ...
- By the university
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Karolinska Institutet