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Anti-COX-2 autoanti...
Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia
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Kelkka, T (author)
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Tyster, M (author)
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Lundgren, S (author)
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Feng, XM (author)
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Kerr, C (author)
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Hosokawa, K (author)
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Huuhtanen, J (author)
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Keranen, M (author)
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Patel, B (author)
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Kawakami, T (author)
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Maeda, Y (author)
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Nieminen, O (author)
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Kasanen, T (author)
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Aronen, P (author)
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Yadav, B (author)
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Rajala, H (author)
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Nakazawa, H (author)
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Jaatinen, T (author)
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- Hellstrom-Lindberg, E (author)
- Karolinska Institutet
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Ogawa, S (author)
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Ishida, F (author)
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Nishikawa, H (author)
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Nakao, S (author)
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Maciejewski, J (author)
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Young, NS (author)
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Mustjoki, S (author)
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(creator_code:org_t)
- 2022-08-05
- 2022
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 36:9, s. 2317-2327
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https://doi.org/10.1...
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Abstract
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- In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened autoantibodies using a microarray containing >9000 proteins and validated the findings in a large international cohort of IAA patients (n = 405) and controls (n = 815). We identified a novel autoantibody that binds to the C-terminal end of cyclooxygenase 2 (COX-2, aCOX-2 Ab). In total, 37% of all adult IAA patients tested positive for aCOX-2 Ab, while only 1.7% of the controls were aCOX-2 Ab positive. Sporadic non-IAA aCOX-2 Ab positive cases were observed among patients with related bone marrow failure diseases, multiple sclerosis, and type I diabetes, whereas no aCOX-2 Ab seropositivity was detected in the healthy controls, in patients with non-autoinflammatory diseases or rheumatoid arthritis. In IAA, anti-COX-2 Ab positivity correlated with age and the HLA-DRB1*15:01 genotype. 83% of the >40 years old IAA patients with HLA-DRB1*15:01 were anti-COX-2 Ab positive, indicating an excellent sensitivity in this group. aCOX-2 Ab positive IAA patients also presented lower platelet counts. Our results suggest that aCOX-2 Ab defines a distinct subgroup of IAA and may serve as a valuable disease biomarker.
Publication and Content Type
- ref (subject category)
- art (subject category)
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Leukemia
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To the university's database
- By the author/editor
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Kelkka, T
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Tyster, M
-
Lundgren, S
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Feng, XM
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Kerr, C
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Hosokawa, K
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show more...
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Huuhtanen, J
-
Keranen, M
-
Patel, B
-
Kawakami, T
-
Maeda, Y
-
Nieminen, O
-
Kasanen, T
-
Aronen, P
-
Yadav, B
-
Rajala, H
-
Nakazawa, H
-
Jaatinen, T
-
Hellstrom-Lindbe ...
-
Ogawa, S
-
Ishida, F
-
Nishikawa, H
-
Nakao, S
-
Maciejewski, J
-
Young, NS
-
Mustjoki, S
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show less...
- Articles in the publication
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Leukemia
- By the university
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Karolinska Institutet