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Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia
- Kelkka, T (author)
- Tyster, M (author)
- Lundgren, S (author)
- show more...
- Feng, XM (author)
- Kerr, C (author)
- Hosokawa, K (author)
- Huuhtanen, J (author)
- Keranen, M (author)
- Patel, B (author)
- Kawakami, T (author)
- Maeda, Y (author)
- Nieminen, O (author)
- Kasanen, T (author)
- Aronen, P (author)
- Yadav, B (author)
- Rajala, H (author)
- Nakazawa, H (author)
- Jaatinen, T (author)
- Ogawa, S (author)
- Ishida, F (author)
- Nishikawa, H (author)
- Nakao, S (author)
- Maciejewski, J (author)
- Young, NS (author)
- Mustjoki, S (author)
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- (creator_code:org_t)
- 2022-08-05
- 2022
- English.
- In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 36:9, s. 2317-2327
- Journal article (peer-reviewed)
Abstract
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- In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened autoantibodies using a microarray containing >9000 proteins and validated the findings in a large international cohort of IAA patients (n = 405) and controls (n = 815). We identified a novel autoantibody that binds to the C-terminal end of cyclooxygenase 2 (COX-2, aCOX-2 Ab). In total, 37% of all adult IAA patients tested positive for aCOX-2 Ab, while only 1.7% of the controls were aCOX-2 Ab positive. Sporadic non-IAA aCOX-2 Ab positive cases were observed among patients with related bone marrow failure diseases, multiple sclerosis, and type I diabetes, whereas no aCOX-2 Ab seropositivity was detected in the healthy controls, in patients with non-autoinflammatory diseases or rheumatoid arthritis. In IAA, anti-COX-2 Ab positivity correlated with age and the HLA-DRB1*15:01 genotype. 83% of the >40 years old IAA patients with HLA-DRB1*15:01 were anti-COX-2 Ab positive, indicating an excellent sensitivity in this group. aCOX-2 Ab positive IAA patients also presented lower platelet counts. Our results suggest that aCOX-2 Ab defines a distinct subgroup of IAA and may serve as a valuable disease biomarker.
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- By the author/editor
- Kelkka, T
- Tyster, M
- Lundgren, S
- Feng, XM
- Kerr, C
- Hosokawa, K
- show more...
- Huuhtanen, J
- Keranen, M
- Patel, B
- Kawakami, T
- Maeda, Y
- Nieminen, O
- Kasanen, T
- Aronen, P
- Yadav, B
- Rajala, H
- Nakazawa, H
- Jaatinen, T
- Hellstrom-Lindbe ...
- Ogawa, S
- Ishida, F
- Nishikawa, H
- Nakao, S
- Maciejewski, J
- Young, NS
- Mustjoki, S
- show less...
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- Leukemia
- By the university
- Karolinska Institutet
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