Search: onr:"swepub:oai:prod.swepub.kib.ki.se:150411234" >
Mobilization of sys...
Mobilization of systemic CCL4 following HIV pre-exposure prophylaxis in young men in Africa
-
Petkov, S (author)
-
Herrera, C (author)
-
Else, L (author)
-
show more...
-
Mugaba, S (author)
-
Namubiru, P (author)
-
Odoch, G (author)
-
Opoka, D (author)
-
Pillay, ADAP (author)
-
Seiphetlo, TB (author)
-
Serwanga, J (author)
-
Ssemata, AS (author)
-
Kaleebu, P (author)
-
Webb, EL (author)
-
Khoo, S (author)
-
Lebina, L (author)
-
Gray, CM (author)
-
Martinson, N (author)
-
Fox, J (author)
-
- Chiodi, F (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2022-07-27
- 2022
- English.
-
In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 965214-
- Related links:
-
http://kipublication...
-
show more...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- HIV-1 pre-exposure prophylaxis (PrEP) relies on inhibition of HIV-1 replication steps. To understand how PrEP modulates the immunological environment, we derived the plasma proteomic profile of men receiving emtricitabine-tenofovir (FTC-TDF) or emtricitabine-tenofovir alafenamide (FTC-TAF) during the CHAPS trial in South Africa and Uganda (NCT03986970). The CHAPS trial randomized 144 participants to one control and 8 PrEP arms, differing by drug type, number of PrEP doses and timing from final PrEP dose to sampling. Blood was collected pre- and post-PrEP. The inflammatory profile of plasma samples was analyzed using Olink (N=92 proteins) and Luminex (N=33) and associated with plasma drug concentrations using mass spectrometry. The proteins whose levels changed most significantly from pre- to post-PrEP were CCL4, CCL3 and TNF-α; CCL4 was the key discriminator between pre- and post-PrEP samples. CCL4 and CCL3 levels were significantly increased in post-PrEP samples compared to control specimens. CCL4 was significantly correlated with FTC drug levels in plasma. Production of inflammatory chemokines CCL4 and CCL3 in response to short-term PrEP indicates the mobilization of ligands which potentially block virus attachment to CCR5 HIV-1 co-receptor. The significant correlation between CCL4 and FTC levels suggests that CCL4 increase is modulated as an inflammatory response to PrEP.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Petkov, S
-
Herrera, C
-
Else, L
-
Mugaba, S
-
Namubiru, P
-
Odoch, G
-
show more...
-
Opoka, D
-
Pillay, ADAP
-
Seiphetlo, TB
-
Serwanga, J
-
Ssemata, AS
-
Kaleebu, P
-
Webb, EL
-
Khoo, S
-
Lebina, L
-
Gray, CM
-
Martinson, N
-
Fox, J
-
Chiodi, F
-
show less...
- Articles in the publication
-
Frontiers in imm ...
- By the university
-
Karolinska Institutet