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Whole blood DNA met...
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
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Barturen, G (author)
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Carnero-Montoro, E (author)
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Martinez-Bueno, M (author)
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Rojo-Rello, S (author)
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Sobrino, B (author)
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Porras-Perales, O (author)
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Alcantara-Dominguez, C (author)
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Bernardo, D (author)
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- Alarcon-Riquelme, ME (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-08-06
- 2022
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 4597-
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https://doi.org/10.1...
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Abstract
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- SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many cases, to bilateral pneumonia, severe dyspnea, and in ~5% of these, death. DNA methylation is known to play an important role in the regulation of the immune processes behind COVID-19 progression, however it has not been studied in depth. In this study, we aim to evaluate the implication of DNA methylation in COVID-19 progression by means of a genome-wide DNA methylation analysis combined with DNA genotyping. The results reveal the existence of epigenomic regulation of functional pathways associated with COVID-19 progression and mediated by genetic loci. We find an environmental trait-related signature that discriminates mild from severe cases and regulates, among other cytokines, IL-6 expression via the transcription factor CEBP. The analyses suggest that an interaction between environmental contribution, genetics, and epigenetics might be playing a role in triggering the cytokine storm described in the most severe cases.
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- art (subject category)
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