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The miR-181 family ...
The miR-181 family regulates colonic inflammation through its activity in the intestinal epithelium
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-09-08
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Rockefeller University Press,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150752125
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150752125URI
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https://doi.org/10.1084/jem.20212278DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The intestinal epithelium is a key physical interface that integrates dietary and microbial signals to regulate nutrient uptake and mucosal immune cell function. The transcriptional programs that regulate intestinal epithelial cell (IEC) quiescence, proliferation, and differentiation have been well characterized. However, how gene expression networks critical for IECs are posttranscriptionally regulated during homeostasis or inflammatory disease remains poorly understood. Herein, we show that a conserved family of microRNAs, miR-181, is significantly downregulated in IECs from patients with inflammatory bowel disease and mice with chemical-induced colitis. Strikingly, we showed that miR-181 expression within IECs, but not the hematopoietic system, is required for protection against severe colonic inflammation in response to epithelial injury in mice. Mechanistically, we showed that miR-181 expression increases the proliferative capacity of IECs, likely through the regulation of Wnt signaling, independently of the gut microbiota composition. As epithelial reconstitution is crucial to restore intestinal homeostasis after injury, the miR-181 family represents a potential therapeutic target against severe intestinal inflammation.
Added entries (persons, corporate bodies, meetings, titles ...)
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Clark, ML
(author)
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Wright, JM
(author)
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Michieletto, MF
(author)
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Liu, SY
(author)
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Erickson, I
(author)
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Dohnalova, L
(author)
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Uhr, GT
(author)
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Tello-Cajiao, J
(author)
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Joannas, L
(author)
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Williams, A
(author)
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Gagliani, N
(author)
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Bewtra, M
(author)
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Tomov, VT
(author)
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Thaiss, CA
(author)
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Henao-Mejia, J
(author)
Related titles
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In:The Journal of experimental medicine: Rockefeller University Press219:121540-95380022-1007
Internet link
Find in a library
To the university's database
- By the author/editor
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Jimenez, MT
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Clark, ML
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Wright, JM
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Michieletto, MF
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Liu, SY
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Erickson, I
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show more...
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Dohnalova, L
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Uhr, GT
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Tello-Cajiao, J
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Joannas, L
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Williams, A
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Gagliani, N
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Bewtra, M
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Tomov, VT
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Thaiss, CA
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Henao-Mejia, J
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet