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A hypothalamic dopa...
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-10-08
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Springer Science and Business Media LLC,2022
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150879357
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150879357URI
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https://doi.org/10.1038/s41467-022-33584-3DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The lateral septum (LS) has been implicated in the regulation of locomotion. Nevertheless, the neurons synchronizing LS activity with the brain’s clock in the suprachiasmatic nucleus (SCN) remain unknown. By interrogating the molecular, anatomical and physiological heterogeneity of dopamine neurons of the periventricular nucleus (PeVN; A14 catecholaminergic group), we find that Th+/Dat1+ cells from its anterior subdivision innervate the LS in mice. These dopamine neurons receive dense neuropeptidergic innervation from the SCN. Reciprocal viral tracing in combination with optogenetic stimulation ex vivo identified somatostatin-containing neurons in the LS as preferred synaptic targets of extrahypothalamic A14 efferents. In vivo chemogenetic manipulation of anterior A14 neurons impacted locomotion. Moreover, chemogenetic inhibition of dopamine output from the anterior PeVN normalized amphetamine-induced hyperlocomotion, particularly during sedentary periods. Cumulatively, our findings identify a hypothalamic locus for the diurnal control of locomotion and pinpoint a midbrain-independent cellular target of psychostimulants.
Added entries (persons, corporate bodies, meetings, titles ...)
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Rebernik, P
(author)
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Pende, M
(author)
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Boi, L
(author)
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Alpar, A
(author)
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Tasan, R
(author)
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Becker, K
(author)
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Balueva, K
(author)
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Saghafi, S
(author)
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Wulff, P
(author)
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Horvath, TL
(author)
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Fisone, GKarolinska Institutet
(author)
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Dodt, HU
(author)
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Hokfelt, TKarolinska Institutet
(author)
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Harkany, TKarolinska Institutet
(author)
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Romanov, RA
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC13:1, s. 5944-2041-1723
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Korchynska, S
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Rebernik, P
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Pende, M
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Boi, L
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Alpar, A
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Tasan, R
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Becker, K
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Balueva, K
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Saghafi, S
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Wulff, P
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Horvath, TL
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Fisone, G
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Dodt, HU
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Hokfelt, T
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Harkany, T
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Romanov, RA
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Nature communica ...
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Karolinska Institutet