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- Marttila, S (author)
Methylation status of VTRNA2-1/nc886 is stable across populations, monozygotic twin pairs and in majority of tissues
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- Future Medicine Ltd,2022
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:150902201
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150902201URI
- https://doi.org/10.2217/epi-2022-0228DOI
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- Language:English
- Summary in:English
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- Aims & methods: The aim of this study was to characterize the methylation level of a polymorphically imprinted gene, VTRNA2-1/ nc886, in human populations and somatic tissues.48 datasets, consisting of more than 30 tissues and >30,000 individuals, were used. Results: nc886 methylation status is associated with twin status and ethnic background, but the variation between populations is limited. Monozygotic twin pairs present concordant methylation, whereas ∼30% of dizygotic twin pairs present discordant methylation in the nc886 locus. The methylation levels of nc886 are uniform across somatic tissues, except in cerebellum and skeletal muscle. Conclusion: The nc886 imprint may be established in the oocyte, and, after implantation, the methylation status is stable, excluding a few specific tissues.
Added entries (persons, corporate bodies, meetings, titles ...)
- Tamminen, H (author)
- Rajic, S (author)
- Mishra, PP (author)
- Lehtimaki, T (author)
- Raitakari, O (author)
- Kahonen, M (author)
- Kananen, LKarolinska Institutet (author)
- Jylhava, JKarolinska Institutet (author)
- Hagg, SKarolinska Institutet (author)
- Delerue, T (author)
- Peters, A (author)
- Waldenberger, M (author)
- Kleber, ME (author)
- Marz, W (author)
- Luoto, R (author)
- Raitanen, J (author)
- Sillanpaa, E (author)
- Laakkonen, EK (author)
- Heikkinen, A (author)
- Ollikainen, M (author)
- Raitoharju, E (author)
- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Epigenomics: Future Medicine Ltd14:18, s. 1105-11241750-192X1750-1911
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- Kahonen, M
- Kananen, L
- Jylhava, J
- Hagg, S
- Delerue, T
- Peters, A
- Waldenberger, M
- Kleber, ME
- Marz, W
- Luoto, R
- Raitanen, J
- Sillanpaa, E
- Laakkonen, EK
- Heikkinen, A
- Ollikainen, M
- Raitoharju, E
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