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T cell responses at...
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression
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- Yazdani, S (author)
- Karolinska Institutet
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- Seitz, C (author)
- Karolinska Institutet
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- Cui, C (author)
- Karolinska Institutet
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- Lovik, A (author)
- Karolinska Institutet
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- Pan, L (author)
- Karolinska Institutet
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Piehl, F (author)
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- Pawitan, Y (author)
- Karolinska Institutet
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- Klappe, U (author)
- Karolinska Institutet
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- Press, R (author)
- Karolinska Institutet
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- Samuelsson, K (author)
- Karolinska Institutet
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Yin, L (author)
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- Vu, TN (author)
- Karolinska Institutet
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Joly, AL (author)
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- Westerberg, LS (author)
- Karolinska Institutet
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- Evertsson, B (author)
- Karolinska Institutet
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- Ingre, C (author)
- Karolinska Institutet
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Andersson, J (author)
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- Fang, F (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-11-08
- 2022
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 6733-
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Abstract
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- Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4+FOXP3− effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides survival, phenotypic profiling of T cells could also predict disease progression rate. Single cell transcriptomics analysis of CSF samples shows clonally expanded CD4+ and CD8+ T cells in CSF, with characteristic gene expression patterns. In summary, T cell responses associate with and likely contribute to disease progression in ALS, supporting modulation of adaptive immunity as a viable therapeutic option.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Yazdani, S
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Seitz, C
-
Cui, C
-
Lovik, A
-
Pan, L
-
Piehl, F
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show more...
-
Pawitan, Y
-
Klappe, U
-
Press, R
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Samuelsson, K
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Yin, L
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Vu, TN
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Joly, AL
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Westerberg, LS
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Evertsson, B
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Ingre, C
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Andersson, J
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Fang, F
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet