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Left Heart Disease ...
Left Heart Disease Phenotype in Elderly Patients with Pulmonary Arterial Hypertension: Insights from the Italian PATRIARCA Registry
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Toma, M (author)
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Miceli, R (author)
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Bonsante, E (author)
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Colombo, D (author)
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Confalonieri, M (author)
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Garascia, A (author)
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Ghio, S (author)
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Lattanzio, M (author)
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Lombardi, CM (author)
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Paciocco, G (author)
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Piccinino, C (author)
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Rota, I (author)
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Santolamazza, C (author)
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Scelsi, L (author)
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Scuri, P (author)
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Stolfo, D (author)
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Vincenzi, A (author)
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Volpiano, L (author)
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Vicenzi, M (author)
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Ameri, P (author)
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- 2022-11-30
- 2022
- English.
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In: Journal of clinical medicine. - : MDPI AG. - 2077-0383. ; 11:23
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https://doi.org/10.3...
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Abstract
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- Pulmonary arterial hypertension (PAH) in the elderly is often associated with left heart disease (LHD), prompting concerns about the use of pulmonary vasodilators. The PATRIARCA registry enrolled ≥70 year-old PAH or chronic thromboembolic pulmonary hypertension (CTEPH) patients at 11 Italian centers from 1 December 2019 through 15 September 2022. After excluding those with CTEPH, post-capillary PH at the diagnostic right heart catheterization (RHC), and/or incomplete data, 23 (33%) of a total of 69 subjects met the criteria proposed in the AMBITION trial to suspect LHD. Diabetes [9 (39%) vs. 6 (13%), p = 0.01] and chronic kidney disease [14 (61%) vs. 12 (26%), p = 0.003] were more common, and the last RHC pulmonary artery wedge pressure [14 ± 5 vs. 10 ± 3 mmHg, p < 0.001] was higher and pulmonary vascular resistance [5.56 ± 3.31 vs. 8.30 ± 4.80, p = 0.02] was lower in LHD than non-LHD patients. However, PAH therapy was similar, with 13 (57%) and 23 (50%) subjects, respectively, taking two oral drugs. PAH medication patterns remained comparable between LHD and non-LHD patients also when the former [37, 54%] were identified by atrial fibrillation and echocardiographic features of LHD, in addition to the AMBITION criteria. In this real-world snapshot, elderly PAH patients were treated with pulmonary vasodilators, including combinations, despite a remarkable prevalence of a LHD phenotype.
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- By the author/editor
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Toma, M
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Miceli, R
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Bonsante, E
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Colombo, D
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Confalonieri, M
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Garascia, A
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show more...
-
Ghio, S
-
Lattanzio, M
-
Lombardi, CM
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Paciocco, G
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Piccinino, C
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Rota, I
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Santolamazza, C
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Scelsi, L
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Scuri, P
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Stolfo, D
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Vincenzi, A
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Volpiano, L
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Vicenzi, M
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Ameri, P
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show less...
- Articles in the publication
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Journal of clini ...
- By the university
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Karolinska Institutet