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MRI data-driven clu...
MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
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- Inguanzo, A (author)
- Karolinska Institutet
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- Poulakis, K (author)
- Karolinska Institutet
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- Mohanty, R (author)
- Karolinska Institutet
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Schwarz, CG (author)
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Przybelski, SA (author)
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Diaz-Galvan, P (author)
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Lowe, VJ (author)
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Boeve, BF (author)
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Lemstra, AW (author)
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van de Beek, M (author)
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van der Flier, W (author)
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Barkhof, F (author)
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Blanc, F (author)
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de Sousa, PL (author)
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Philippi, N (author)
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Cretin, B (author)
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Demuynck, C (author)
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Nedelska, Z (author)
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Hort, J (author)
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Segura, B (author)
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Junque, C (author)
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Oppedal, K (author)
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- Aarsland, D (author)
- Karolinska Institutet
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- Westman, E (author)
- Karolinska Institutet
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Kantarci, K (author)
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- Ferreira, D (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2023-01-20
- 2023
- English.
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In: NPJ Parkinson's disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 9:1, s. 5-
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Abstract
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- Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
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- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Inguanzo, A
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Poulakis, K
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Mohanty, R
-
Schwarz, CG
-
Przybelski, SA
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Diaz-Galvan, P
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show more...
-
Lowe, VJ
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Boeve, BF
-
Lemstra, AW
-
van de Beek, M
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van der Flier, W
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Barkhof, F
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Blanc, F
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de Sousa, PL
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Philippi, N
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Cretin, B
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Demuynck, C
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Nedelska, Z
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Hort, J
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Segura, B
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Junque, C
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Oppedal, K
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Aarsland, D
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Westman, E
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Kantarci, K
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Ferreira, D
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show less...
- Articles in the publication
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NPJ Parkinson's ...
- By the university
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Karolinska Institutet