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Neuromotor repertoi...
Neuromotor repertoires in infants exposed to maternal COVID-19 during pregnancy: a cohort study
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Martinez, VF (author)
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Zhang, D (author)
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Paiola, S (author)
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Mok, T (author)
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Cambou, MC (author)
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Kerin, T (author)
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Rao, R (author)
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Brasil, P (author)
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Ferreira, F (author)
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Fuller, T (author)
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Bhattacharya, D (author)
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Foo, SS (author)
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Chen, W (author)
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Jung, J (author)
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Einspieler, C (author)
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- Marschik, PB (author)
- Karolinska Institutet
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Nielsen-Saines, K (author)
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(creator_code:org_t)
- 2023-01-23
- 2023
- English.
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In: BMJ open. - : BMJ. - 2044-6055. ; 13:1, s. e069194-
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Abstract
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- To evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19.DesignLongitudinal cohort study.SettingHospital-based study in Los Angeles, USA and Rio de Janeiro, Brazil between March 2020 and December 2021.ParticipantsInfants born to mothers with COVID-19 during pregnancy and prepandemic control infants from the Graz University Database.InterventionsGeneral movement assessment (GMA) videos between 3 and 5 months post-term age were collected and clinical assessments/developmental milestones evaluated at 6–8 months of age. Cases were matched by gestational age, gender and post-term age to prepandemic neurotypical unexposed controls from the database.Main outcome measuresMotor Optimality Scores Revised (MOS-R) at 3–5 months. Presence of developmental delay (DD) at 6–8 months.Results239 infants were enrolled; 124 cases (83 in the USA/41 in Brazil) and 115 controls. GMA was assessed in 115 cases and 115 controls; 25% were preterm. Median MOS-R in cases was 23 (IQR 21–24, range 9–28) vs 25 (IQR 24–26, range 20–28) in controls, p<0.001. Sixteen infants (14%) had MOS-R scores <20 vs zero controls, p<0.001. At 6–8 months, 13 of 109 case infants (12%) failed to attain developmental milestones; all 115 control infants had normal development. The timing of maternal infection in pregnancy (first, second or third trimester) or COVID-19 disease severity (NIH categories asymptomatic, mild/moderate or severe/critical) was not associated with suboptimal MOS-R or DD. Maternal fever in pregnancy was associated with DD (OR 3.7; 95% CI 1.12 to 12.60) but not suboptimal MOS-R (OR 0.25; 95% CI 0.04 to 0.96).ConclusionsCompared with prepandemic controls, infants exposed to antenatal COVID-19 more frequently had suboptimal neuromotor development.
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BMJ open
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To the university's database
- By the author/editor
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Martinez, VF
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Zhang, D
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Paiola, S
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Mok, T
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Cambou, MC
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Kerin, T
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show more...
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Rao, R
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Brasil, P
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Ferreira, F
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Fuller, T
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Bhattacharya, D
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Foo, SS
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Chen, W
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Jung, J
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Einspieler, C
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Marschik, PB
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Nielsen-Saines, ...
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show less...
- Articles in the publication
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BMJ open
- By the university
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Karolinska Institutet