Cerebral Edema in Patients with severe Hemispheric Syndrome: Incidence, Risk Factors, and Outcomes-Data from SITS-ISTR

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:prod.swepub.kib.ki.se:152011327" > Cerebral Edema in P...

1 of 1
Previous record
Next record
To hitlist

Details
MARC

Escudero-Martinez, I (author)

Cerebral Edema in Patients with severe Hemispheric Syndrome: Incidence, Risk Factors, and Outcomes-Data from SITS-ISTR

Article/chapterEnglish2023

Publisher, publication year, extent ...

Korean Stroke Society,2023

Numbers

LIBRIS-ID:oai:prod.swepub.kib.ki.se:152011327
http://kipublications.ki.se/Default.aspx?queryparsed=id:152011327URI
https://doi.org/10.5853/jos.2022.01956DOI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background and Purpose Cerebral edema (CED) in ischemic stroke can worsen prognosis and about 70% of patients who develop severe CED die if treated conservatively. We aimed to describe incidence, risk factors and outcomes of CED in patients with extensive ischemia.Methods Oservational study based on Safe Implementation of Treatments in Stroke-International Stroke Treatment Registry (2003–2019). Severe hemispheric syndrome (SHS) at baseline and persistent SHS (pSHS) at 24 hours were defined as National Institutes of Health Stroke Score (NIHSS) >15. Outcomes were moderate/severe CED detected by neuroimaging, functional independence (modified Rankin Scale 0–2) and death at 90 days.Results Patients (n=8,560) presented with SHS and developed pSHS at 24 hours; 82.2% received intravenous thrombolysis (IVT), 10.5% IVT+thrombectomy, and 7.3% thrombectomy alone. Median age was 77 and NIHSS 21. Of 7,949 patients with CED data, 3,780 (47.6%) had any CED and 2,297 (28.9%) moderate/severe CED. In the multivariable analysis, age <50 years (relative risk [RR], 1.56), signs of acute infarct (RR, 1.29), hyperdense artery sign (RR, 1.39), blood glucose >128.5 mg/dL (RR, 1.21), and decreased level of consciousness (RR, 1.14) were associated with moderate/severe CED (for all P<0.05). Patients with moderate/severe CED had lower odds to achieve functional Independence (adjusted odds ratio [aOR], 0.35; 95% confidence interval [CI], 0.23 to 0.55) and higher odds of death at 90 days (aOR, 2.54; 95% CI, 2.14 to 3.02).Conclusions In patients with extensive ischemia, the most important predictors for moderate/ severe CED were age <50, high blood glucose, signs of acute infarct, hyperdense artery on baseline scans, and decreased level of consciousness. CED was associated with worse functional outcome and a higher risk of death at 3 months.

Added entries (persons, corporate bodies, meetings, titles ...)

Thoren, MKarolinska Institutet (author)
Ringleb, P (author)
Nunes, AP (author)
Cappellari, M (author)
Rand, VM (author)
Sobolewski, P (author)
Egido, J (author)
Toni, D (author)
Chen, SY (author)
Tsao, N (author)
Ahmed, NKarolinska Institutet (author)
Karolinska Institutet (creator_code:org_t)

Related titles

In:Journal of stroke: Korean Stroke Society25:1, s. 101-+2287-63912287-6405

Internet link

Find in a library

Journal of stroke (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Escudero-Martine ...; Thoren, M; Ringleb, P; Nunes, AP; Cappellari, M; Rand, VM; show more...; Sobolewski, P; Egido, J; Toni, D; Chen, SY; Tsao, N; Ahmed, N; show less...

Articles in the publication: Journal of strok ...

By the university: Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se