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Targeted plasma pro...
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Medina, LMPKarolinska Institutet
(author)
Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-24
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Springer Science and Business Media LLC,2023
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:152034848
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http://kipublications.ki.se/Default.aspx?queryparsed=id:152034848URI
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https://doi.org/10.1186/s12931-023-02364-yDOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BackgroundCOVID-19 remains a major public health challenge, requiring the development of tools to improve diagnosis and inform therapeutic decisions. As dysregulated inflammation and coagulation responses have been implicated in the pathophysiology of COVID-19 and sepsis, we studied their plasma proteome profiles to delineate similarities from specific features.MethodsWe measured 276 plasma proteins involved in Inflammation, organ damage, immune response and coagulation in healthy controls, COVID-19 patients during acute and convalescence phase, and sepsis patients; the latter included (i) community-acquired pneumonia (CAP) caused by Influenza, (ii) bacterial CAP, (iii) non-pneumonia sepsis, and (iv) septic shock patients.ResultsWe identified a core response to infection consisting of 42 proteins altered in both COVID-19 and sepsis, although higher levels of cytokine storm-associated proteins were evident in sepsis. Furthermore, microbiologic etiology and clinical endotypes were linked to unique signatures. Finally, through machine learning, we identified biomarkers, such as TRIM21, PTN and CASP8, that accurately differentiated COVID-19 from CAP-sepsis with higher accuracy than standard clinical markers.ConclusionsThis study extends the understanding of host responses underlying sepsis and COVID-19, indicating varying disease mechanisms with unique signatures. These diagnostic and severity signatures are candidates for the development of personalized management of COVID-19 and sepsis.
Added entries (persons, corporate bodies, meetings, titles ...)
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Babacic, HKarolinska Institutet
(author)
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Dzidic, M
(author)
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Parke, AKarolinska Institutet
(author)
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Garcia, M
(author)
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Maleki, KTKarolinska Institutet
(author)
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Unge, C
(author)
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Lourda, MKarolinska Institutet
(author)
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Kvedaraite, EKarolinska Institutet
(author)
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Chen, PR
(author)
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Muvva, JR
(author)
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Cornillet, M
(author)
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Emgard, J
(author)
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Moll, KKarolinska Institutet
(author)
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Michaelsson, JKarolinska Institutet
(author)
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Flodstrom-Tullberg, MKarolinska Institutet
(author)
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Brighenti, SKarolinska Institutet
(author)
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Buggert, MKarolinska Institutet
(author)
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Mjosberg, JKarolinska Institutet
(author)
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Malmberg, KJKarolinska Institutet
(author)
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Sandberg, JKKarolinska Institutet
(author)
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Gredmark-Russ, SKarolinska Institutet
(author)
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Rooyackers, OKarolinska Institutet
(author)
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Svensson, MKarolinska Institutet
(author)
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Chambers, BJKarolinska Institutet
(author)
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Eriksson, LIKarolinska Institutet
(author)
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Pernemalm, MKarolinska Institutet
(author)
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Bjorkstrom, NKarolinska Institutet
(author)
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Aleman, SKarolinska Institutet
(author)
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Ljunggren, HGKarolinska Institutet
(author)
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Klingstrom, JKarolinska Institutet
(author)
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Stralin, KKarolinska Institutet
(author)
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Norrby-Teglund, AKarolinska Institutet
(author)
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Karolinska Institutet
(creator_code:org_t)
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In:Respiratory research: Springer Science and Business Media LLC24:1, s. 62-1465-993X
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Medina, LMP
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Babacic, H
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Dzidic, M
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Parke, A
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Garcia, M
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Maleki, KT
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Unge, C
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Lourda, M
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Kvedaraite, E
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Chen, PR
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Muvva, JR
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Cornillet, M
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Emgard, J
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Moll, K
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Michaelsson, J
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Flodstrom-Tullbe ...
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Brighenti, S
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Buggert, M
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Mjosberg, J
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Malmberg, KJ
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Sandberg, JK
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Gredmark-Russ, S
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Rooyackers, O
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Svensson, M
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Chambers, BJ
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Eriksson, LI
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Pernemalm, M
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Bjorkstrom, N
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Aleman, S
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Ljunggren, HG
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Klingstrom, J
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Stralin, K
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Norrby-Teglund, ...
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