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Outcome of COVID-19...
Outcome of COVID-19 in allogeneic stem cell transplant recipients: Results from the EPICOVIDEHA registry
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Busca, A (author)
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Salmanton-Garcia, J (author)
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Marchesi, F (author)
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Farina, F (author)
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Seval, GC (author)
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Van Doesum, J (author)
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De Jonge, N (author)
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Bahr, NC (author)
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Maertens, J (author)
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Meletiadis, J (author)
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Fracchiolla, NS (author)
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Weinbergerova, B (author)
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Verga, L (author)
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Racil, Z (author)
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Jimenez, M (author)
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Glenthoj, A (author)
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- Blennow, O (author)
- Karolinska Institutet
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Tanase, AD (author)
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Schonlein, M (author)
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Prezioso, L (author)
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Khanna, N (author)
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Duarte, RF (author)
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Zak, P (author)
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Nucci, M (author)
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Machado, M (author)
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Kulasekararaj, A (author)
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Espigado, I (author)
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De Kort, E (author)
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Susana, JMRS (author)
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Marchetti, M (author)
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Magliano, G (author)
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Falces-Romero, I (author)
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Ilhan, O (author)
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Ammatuna, E (author)
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Zompi, S (author)
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Tsirigotis, P (author)
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Antoniadou, A (author)
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Zambrotta, GPM (author)
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- Nordlander, A (author)
- Karolinska Institutet
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Karlsson, LK (author)
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Hanakova, M (author)
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Dragonetti, G (author)
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Cabirta, A (author)
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Venemyr, CB (author)
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Grafe, S (author)
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Van Praet, J (author)
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Tragiannidis, A (author)
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Petzer, V (author)
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Lopez-Garcia, A (author)
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Itri, F (author)
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Groh, A (author)
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Gavriilaki, E (author)
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Dargenio, M (author)
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Rahimli, L (author)
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Cornely, OA (author)
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Pagano, L (author)
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(creator_code:org_t)
- 2023-02-24
- 2023
- English.
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In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 14, s. 1125030-
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http://kipublication...
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https://doi.org/10.3...
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Abstract
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- The outcome of COVID-19 in allogeneic hematopoietic stem cell transplantation (HSCT) recipients is almost uniformely considered poor. The aim of present study was to retrospectively analyse the outcome and risk factors for mortality in a large series of patients who developed COVID-19 infection after an allogeneic HSCT.MethodsThis multicenter retrospective study promoted by the European Hematology Association – Infections in Hematology Study Working Group, included 326 adult HSCT patients who had COVID-19 between January 2020 and March 2022.ResultsThe median time from HSCT to the diagnosis of COVID-19 was 268 days (IQR 86-713; range 0-185 days). COVID-19 severity was mild in 21% of the patients, severe in 39% and critical in 16% of the patients. In multivariable analysis factors associated with a higher risk of mortality were, age above 50 years, presence of 3 or more comorbidities, active hematologic disease at time of COVID-19 infection, development of COVID-19 within 12 months of HSCT, and severe/critical infections. Overall mortality rate was 21% (n=68): COVID-19 was the main or secondary cause of death in 16% of the patients (n=53).ConclusionsMortality in HSCT recipients who develop COVID-19 is high and largely dependent on age, comorbidities, active hematologic disease, timing from transplant and severity of the infection.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Busca, A
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Salmanton-Garcia ...
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Marchesi, F
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Farina, F
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Seval, GC
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Van Doesum, J
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show more...
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De Jonge, N
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Bahr, NC
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Maertens, J
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Meletiadis, J
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Fracchiolla, NS
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Weinbergerova, B
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Verga, L
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Racil, Z
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Jimenez, M
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Glenthoj, A
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Blennow, O
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Tanase, AD
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Schonlein, M
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Prezioso, L
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Khanna, N
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Duarte, RF
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Zak, P
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Nucci, M
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Machado, M
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Kulasekararaj, A
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Espigado, I
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De Kort, E
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Susana, JMRS
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Marchetti, M
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Magliano, G
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Falces-Romero, I
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Ilhan, O
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Ammatuna, E
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Zompi, S
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Tsirigotis, P
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Antoniadou, A
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Zambrotta, GPM
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Nordlander, A
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Karlsson, LK
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Hanakova, M
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Dragonetti, G
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Cabirta, A
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Venemyr, CB
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Grafe, S
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Van Praet, J
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Tragiannidis, A
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Petzer, V
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Lopez-Garcia, A
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Itri, F
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Groh, A
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Gavriilaki, E
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Dargenio, M
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Rahimli, L
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Cornely, OA
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Pagano, L
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show less...
- Articles in the publication
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Frontiers in imm ...
- By the university
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Karolinska Institutet