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Postnatal growth re...
Postnatal growth restriction and neurodevelopment at 5 years of age: a European extremely preterm birth cohort study
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El Rafei, R (author)
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Maier, RF (author)
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Jarreau, PH (author)
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- Norman, M (author)
- Karolinska Institutet
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Barros, H (author)
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Van Reempts, P (author)
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Van Heijst, A (author)
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Pedersen, P (author)
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Cuttini, M (author)
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Johnson, S (author)
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Costa, R (author)
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Zemlin, M (author)
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Draper, ES (author)
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Zeitlin, J (author)
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(creator_code:org_t)
- 2023-03-03
- 2023
- English.
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In: Archives of disease in childhood. Fetal and neonatal edition. - : BMJ. - 1468-2052 .- 1359-2998. ; 108:5, s. F492-F498
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Abstract
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- To investigate whether extrauterine growth restriction (EUGR) during the neonatal hospitalisation by sex among extremely preterm (EPT) infants is associated with cerebral palsy (CP) and cognitive and motor abilities at 5 years of age.Study designPopulation-based cohort of births <28 weeks of gestation with data from obstetric and neonatal records and parental questionnaires and clinical assessments at 5 years of age.Setting11 European countries.Patients957 EPT infants born in 2011–2012.Main outcomesEUGR at discharge from the neonatal unit was defined as (1) the difference between Z-scores at birth and discharge with <−2 SD as severe, −2 to −1 SD as moderate using Fenton’s growth charts (Fenton) and (2) average weight-gain velocity using Patel’s formula in grams (g) per kilogram per day (Patel) with <11.2 g (first quartile) as severe, 11.2–12.5 g (median) as moderate. Five-year outcomes were: a CP diagnosis, intelligence quotient (IQ) using the Wechsler Preschool and Primary Scales of Intelligence tests and motor function using the Movement Assessment Battery for Children, second edition.Results40.1% and 33.9% children were classified as having moderate and severe EUGR, respectively, by Fenton and 23.8% and 26.3% by Patel. Among children without CP, those with severe EUGR had lower IQ than children without EUGR (−3.9 points, 95% Confidence Interval (CI)=−7.2 to −0.6 for Fenton and −5.0 points, 95% CI=−8.2 to −1.8 for Patel), with no interaction by sex. No significant associations were observed between motor function and CP.ConclusionsSevere EUGR among EPT infants was associated with decreased IQ at 5 years of age.
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- By the author/editor
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El Rafei, R
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Maier, RF
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Jarreau, PH
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Norman, M
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Barros, H
-
Van Reempts, P
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show more...
-
Van Heijst, A
-
Pedersen, P
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Cuttini, M
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Johnson, S
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Costa, R
-
Zemlin, M
-
Draper, ES
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Zeitlin, J
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show less...
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Archives of dise ...
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Karolinska Institutet