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  • Arefin, SKarolinska Institutet (author)

Associations of Biopterins and ADMA with Vascular Function in Peripheral Microcirculation from Patients with Chronic Kidney Disease

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-03-15
  • MDPI AG,2023

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:152350642
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152350642URI
  • https://doi.org/10.3390/ijms24065582DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We hypothesized that patients with chronic kidney disease (CKD) display an altered plasma amino acid (AA) metabolomic profile that could contribute to abnormal vascular maintenance of peripheral circulation in uremia. The relationships between plasma AAs and endothelial and vascular smooth muscle function in the microcirculation of CKD patients are not well understood. The objective of this study is to investigate to what extent the levels of AAs and its metabolites are changed in CKD patients and to test their relationship with endothelial and vascular smooth muscle function. Patients with CKD stages 3 and 5 and non-CKD controls are included in this study. We report that there was a significant reduction of the biopterin (BH4/BH2) ratio, which was accompanied by increased plasma levels of BH2, asymmetric dimethylarginine (ADMA) and citrulline in patients with CKD-5 vs. CKD-3 vs. controls. In vivo augmentation index measurement showed a positive association with ADMA in all participants. The contribution of nitric oxide, assessed by ex vivo assay, showed a negative association with creatinine, ADMA and citrulline in all participants. In CKD-5, BH4 negatively correlated with ADMA and ornithine levels, and the ex vivo endothelium-mediated dilatation positively correlated with phenylalanine levels. In conclusion, uremia is associated with alterations in AA metabolism that may affect endothelium-dependent dilatation and vascular stiffness in microcirculation. Interventional strategies aiming to normalize the AA metabolism could be of interest as treatment options.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lofgren, L (author)
  • Stenvinkel, PKarolinska Institutet (author)
  • Granqvist, AB (author)
  • Kublickiene, KKarolinska Institutet (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:International journal of molecular sciences: MDPI AG24:61422-0067

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