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Centenarian clocks: epigenetic clocks for validating claims of exceptional longevity
- Dec, E (author)
- Clement, J (author)
- Cheng, KY (author)
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- Church, GM (author)
- Fossel, MB (author)
- Rehkopf, DH (author)
- Rosero-Bixby, L (author)
- Kobor, MS (author)
- Lin, DTS (author)
- Lu, AT (author)
- Fei, Z (author)
- Guo, W (author)
- Chew, YC (author)
- Yang, XJ (author)
- Putra, SED (author)
- Reiner, AP (author)
- Correa, A (author)
- Vilalta, A (author)
- Pirazzini, C (author)
- Passarino, G (author)
- Monti, D (author)
- Arosio, B (author)
- Franceschi, C (author)
- Horvath, S (author)
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- (creator_code:org_t)
- 2023-03-25
- 2023
- English.
- In: GeroScience. - : Springer Science and Business Media LLC. - 2509-2723 .- 2509-2715. ; 45:43, s. 1817-1835
- Journal article (peer-reviewed)
Abstract
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- Claims surrounding exceptional longevity are sometimes disputed or dismissed for lack of credible evidence. Here, we present three DNA methylation-based age estimators (epigenetic clocks) for verifying age claims of centenarians. The three centenarian clocks were developed based on n = 7039 blood and saliva samples from individuals older than 40, including n = 184 samples from centenarians, 122 samples from semi-supercentenarians (aged 105 +), and 25 samples from supercentenarians (aged 110 +). The oldest individual was 115 years old. Our most accurate centenarian clock resulted from applying a neural network model to a training set composed of individuals older than 40. An epigenome-wide association study of age in different age groups revealed that age effects in young individuals (age < 40) are correlated (r = 0.55) with age effects in old individuals (age > 90). We present a chromatin state analysis of age effects in centenarians. The centenarian clocks are expected to be useful for validating claims surrounding exceptional old age.
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- By the author/editor
- Dec, E
- Clement, J
- Cheng, KY
- Church, GM
- Fossel, MB
- Rehkopf, DH
- show more...
- Rosero-Bixby, L
- Kobor, MS
- Lin, DTS
- Lu, AT
- Fei, Z
- Guo, W
- Chew, YC
- Yang, XJ
- Putra, SED
- Reiner, AP
- Correa, A
- Vilalta, A
- Pirazzini, C
- Passarino, G
- Monti, D
- Arosio, B
- Garagnani, P
- Franceschi, C
- Horvath, S
- show less...
- Articles in the publication
- GeroScience
- By the university
- Karolinska Institutet
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